0000000000199842

AUTHOR

Gert Lange

showing 3 related works from this author

Intratympanic gentamicin treatment after endolymphatic sac surgery.

2005

Interval treatment with up to three intratympanic gentamicin injections once weekly effectively controlled vertigo while preserving hearing in patients with Ménière's disease and recurrent or resistant vertigo after saccotomy.Recurrent or resistant incapacitating vertigo may occur after endolymphatic sac surgery (saccotomy) in patients with Ménière's disease. In these patients, revision saccotomy, vestibular nerve section or labyrinthectomy are the established treatment options. We advocate a once-weekly application of intratympanic gentamicin (12 mg) as an effective alternative in this group of patients.Five patients (age range 39-65 years) with definite Ménière's disease according to the …

AdultMalemedicine.medical_specialtyEar MiddleEndolymphatic sacInjectionsPostoperative ComplicationsRecurrenceVertigootorhinolaryngologic diseasesmedicineHumansEndolymphatic HydropsEndolymphatic hydropsMeniere DiseaseAntibacterial agentAgedbiologymedicine.diagnostic_testbusiness.industryAminoglycosideElectronystagmographyAuditory ThresholdGeneral MedicineMiddle Agedbiology.organism_classificationmedicine.diseaseSurgerymedicine.anatomical_structureOtorhinolaryngologyElectronystagmographyVertigoAudiometry Pure-ToneGentamicinFemaleEndolymphatic SacGentamicinsbusinessmedicine.drugMeniere's diseaseFollow-Up StudiesActa oto-laryngologica
researchProduct

Intratympanale Intervalltherapie des Morbus Meni�re mit Gentamicin unter Erhalt der Kochleafunktion

2003

Patienten und Methode Zwischen 1997 und 2000 haben wir 57 Patienten intratympanal einseitig mit Gentamicininjektionen (jeweils 0,3 ml = 12 mg) therapiert. Eine Therapieserie bestand maximal aus je einer Injektion an Tag 1, 8 und 15. Intratympanal injiziertes Gentamicin akkumuliert langsam (Durchschnitt unseres Krankenguts: 4,6 Tage) im Innenohr. Die Intervalltherapie vermeidet uberhohte Gentamicinkonzentrationen. Sobald Zeichen einer Innenohrreaktion auftreten (Nystagmus, Unsicherheit, Schwindel), hat die Therapie gewirkt und darf keinesfalls weitergefuhrt werden.

MENIERE DISEASEGynecologymedicine.medical_specialtyOtorhinolaryngologybusiness.industryHead and neck surgeryMedicinebusinessAntibacterial agentHNO
researchProduct

Long-Term Results after Interval Therapy with Intratympanic Gentamicin for Meni??re???s Disease

2004

Objectives The new single-shot and interval treatment for Meniere's disease with gentamicin was designed to avoid cochlear damage during treatment with gentamicin. Methods To date, 90 patients were treated with the single-shot or interval gentamicin therapy. Fifty-seven cases of Meniere's disease were followed up prospectively between 2 and 4 years. During one treatment series, a maximum of three intratympanic gentamicin injections within 15 days were applied, each consisting of 0.3 mL (12 mg) of gentamicin (days 1, 8, and 15). Thirty of these 57 patients (53%) needed only one injection to be controlled (single-shot treatment). Results Vertigo attacks were completely controlled in 95% and p…

Malemedicine.medical_specialtyTime FactorsTympanic MembraneHearing lossDrug Administration ScheduleOtotoxicityVertigomedicineHumansProspective StudiesMeniere DiseaseAntibacterial agentbiologybusiness.industryAminoglycosideMiddle Agedmedicine.diseasebiology.organism_classificationAnti-Bacterial AgentsSurgeryTreatment OutcomeOtorhinolaryngologyFemaleGentamicinGentamicinsmedicine.symptombusinessTinnitusFollow-Up StudiesMeniere's diseasemedicine.drugThe Laryngoscope
researchProduct