0000000000201154

AUTHOR

Nigel K Arden

showing 3 related works from this author

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

2011

Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…

Malenivelrikkomedicine.medical_specialtygenetiikkaBiomedical EngineeringMEDLINEdiagnostiset kriteeritOsteoarthritisbehavioral disciplines and activitiesArticleCohort Studies03 medical and health sciencesRotterdam Study0302 clinical medicineRheumatologyInternal medicineTREATOAOsteoarthritismedicinePrevalenceGeneticsHumansOrthopedics and Sports Medicine030304 developmental biologyRheumatology and Autoimmunity2. Zero hunger030203 arthritis & rheumatology0303 health sciencesAnalysis of Varianceperinnöllisyystiedebusiness.industryCase-control studyDefinitionReference Standardsmedicine.diseaseGenetics Osteoarthritis Phenotype Definition TREATOA genome-wide association radiographic hip osteoarthritis bone-mineral density knee osteoarthritis hand osteoarthritis osteoporotic fractures general-population joint involvement risk-factors susceptibilityRheumatology3. Good healthPhenotypeCase-Control Studiesdiagnostic criteriaCohortPhysical therapyFemalebusinessBody mass indexCohort study
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An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteopor…

2019

Objectives: The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) sought to revisit the 2014 algorithm recommendations for knee osteoarthritis (OA), in light of recent efficacy and safety evidence, in order to develop an updated stepwise algorithm that provides practical guidance for the prescribing physician that is applicable in Europe and internationally. Methods: Using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) process, a summary of evidence document for each intervention in OA was provided to all members of an ESCEO working group, who were required to evaluate and vote on the streng…

ConsensusMedicinaOsteoporosisPsychological interventionOsteoarthritisRecommendations03 medical and health sciences0302 clinical medicineRheumatologyIntervention (counseling)MedicineHumans030212 general & internal medicineGrading (education)Societies Medical030203 arthritis & rheumatologyddc:616business.industryDisease ManagementRecommendationOsteoarthritis Kneemedicine.diseaseEuropeAlgorithmTreatmentAnesthesiology and Pain MedicineGRADEKnee osteoarthritisbusinessAlgorithmStepwise approachKnee osteoarthritiAlgorithms
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Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinica…

2017

Objectives To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need. Methods The European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO) organized a working group under the auspices of the International Osteoporosis Foundation (IOF) and the World Health Organization (WHO). Results This consensus guideline is intended to provide a reference tool for practice, and should allow for better standardization of the conduct of clinical trials in hand OA. Hand OA is …

medicine.medical_specialtyConsensusStandardizationHand JointsOsteoporosisOsteoarthritisDiseaseGuidelinesArticle03 medical and health sciences0302 clinical medicineClinical trialsRheumatologyOsteoarthritisHand osteoarthritismedicineHumans030212 general & internal medicineIntensive care medicineClinical trials; Guidelines; Hand osteoarthritis; Pharmacological treatment030203 arthritis & rheumatologyClinical Trials as Topicbusiness.industryclinical trialmedicine.diseaseClinical trialAnesthesiology and Pain MedicineResearch DesignExpert opinionAntirheumatic Agentshand osteoarthritibusinessguidelinePharmacological treatmentHand osteoarthritisConsensus guideline
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