0000000000201158
AUTHOR
Arpo Aromaa
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…
Postural Balance in a Random Sample of 7,979 Subjects Aged 30 Years and Over
<i>Background:</i> Reliable normative data for force platform measurements of postural balance have not been available. <i>Methods:</i> Data on postural balance were collected from a representative nationwide sample of a Finnish population aged ≧30 years (n = 7,979). As part of a comprehensive health survey <i>(Health 2000)</i>, postural balance was measured with the help of a force platform system in four test conditions: normal standing with eyes open and closed (both for 30 s), semi-tandem (20 s) and tandem stand with eyes open (20 s). In addition, balance abilities were also evaluated by a non-instrumented field test. <i>Results:</i> The m…
Thirty-one novel biomarkers as predictors for clinically incident diabetes.
Background The prevalence of diabetes is increasing in all industrialized countries and its prevention has become a public health priority. However, the predictors of diabetes risk are insufficiently understood. We evaluated, whether 31 novel biomarkers could help to predict the risk of incident diabetes. Methods and Findings The biomarkers were evaluated primarily in the FINRISK97 cohort (n = 7,827; 417 cases of clinically incident diabetes during the follow-up). The findings were replicated in the Health 2000 cohort (n = 4,977; 179 cases of clinically incident diabetes during the follow-up). We used Cox proportional hazards models to calculate the relative risk of diabetes, after adjustin…
Psychomotor speed in a random sample of 7,979 subjects aged 30 years and over.
Background and aims: Slowing of psychomotor speed among older individuals has been shown in numerous studies. However, in most cases these studies were based on small and selected groups of people and, in some cases, the test procedures did not allow separation of decision time and motor components of the overall performance. The purpose of the present study was to analyse in a large, randomly selected population sample the differences in decision and movement times in simple and multiple-choice test conditions. The association of educational background with psychomotor speed was also examined. Methods: Data on psychomotor speed were collected from a representative nation-wide sample of the…
Sero-epidemiologal association between human-papillomavirus infection and risk of prostate cancer
Some epidemiological studies of prostate cancer have suggested the existence of a sexually transmitted risk factor, and some studies have reported the presence of human papillomavirus (HPV) DNA in prostate-cancer tissue. To perform a sero-epidemiological evaluation of whether HPV infection is associated with increased risk for prostate cancer, we performed a nested case-control study within a serum bank containing samples from 20,243 healthy Finnish men. We identified 165 cases of prostate cancer that were diagnosed up to 24 years after donation of the serum sample. Two control subjects per case were selected, matched for gender, age and municipality of residence. Serum samples were analyze…
Cardiovascular Risk in Young Finns
This report describes the general outline and progress of a multicentre study on risk factors of coronary heart disease and their determinants in children and adolescents. "Cardiovascular Risk in Young Finns" comprises a cross-sectional study of 3 to 18-year old subjects in 1980, and follow-up studies in 1983 and 1986 in various parts of Finland, and in 1989 in one of the study areas (Turku). The number of participants in 1980 was 3596 (83.1%) of those invited. In 1983 and 1986 83.2% and 77.8% of them, respectively, participated. The study programme has comprised questionnaire data on, for example, general health and living conditions, physical activity, eating habits, smoking, and psycholo…