0000000000202503
AUTHOR
Myung-eun Suh
Regioselective substitution of 6,7-dichloroquinoline-5,8-dione: synthesis and X-ray crystal structure of 4a,10,11-triazabenzo[3,2-a]fluorene-5,6-diones
6,7-Dichloroquinoline-5,8-dione (1) was reacted with a number of 2-aminopyridine derivatives. Of the several possible products of this reaction, 4a,10,11-triazabenzo[3,2-a]fluorene-5,6-dione (6), produced by condensation and rearrangement, was obtained as the major product, and its structure was subsequently unambigously determined by X-ray crystallographic study. Ortho-quinones were produced via nucleophilic substitution at position C7, which was unexpected, considering that para-quinones were produced via C6 substitution in the reaction between compound 1 and ethyl acetoacetate in our previous work. Such unexpected nucleophilic substitution at C7 provides an effective, yet simple route, t…
Synthesis and cytotoxicity of 6,11-Dihydro-pyrido- and 6,11-Dihydro-benzo[2,3-b]phenazine-6,11-dione derivatives
6,11-Dihydro-pyrido[2,3-b]phenazine-6,11-diones and 6,11-dihydro-benzo[2,3-b]phenazine-6,11-diones were synthesized from 6,7-dichloro-5,8-quinolinedione and 2,3-dichloro-1,4-naphthoquinone. The study on the cytotoxicity on these products revealed that the pyridophenazinediones, tetracyclic heteroquinone analogues with three nitrogen atoms exhibited a high cytotoxicity on several human tumor cell lines. Compound 9c and 9e showed in vitro antitumor activity comparable or superior to doxorubicin against the human ovarian tumor cells (SK-OV-3) and the human CNS cells (XF 498). The IC(50) value for compound 9e was 0.06 microM against the human CNS cells (XF 498), which was 2.6 times higher than …
CCDC 196626: Experimental Crystal Structure Determination
Related Article: Young-Shin Kim, Se-Young Park, Hyun-Jung Lee, Myung-Eun Suh, D.Schollmeyer, Chong-Ock Lee|2003|Bioorg.Med.Chem.|11|1709|doi:10.1016/S0968-0896(03)00028-2
CCDC 190701: Experimental Crystal Structure Determination
Related Article: Young-Shin Kim, So-Young Park, Myung-Eun Suh, Hyun-Jung Lee, D.Schollmeyer|2003|Bioorg.Med.Chem.|11|1829|doi:10.1016/S0968-0896(02)00667-3
CCDC 196625: Experimental Crystal Structure Determination
Related Article: Young-Shin Kim, Se-Young Park, Hyun-Jung Lee, Myung-Eun Suh, D.Schollmeyer, Chong-Ock Lee|2003|Bioorg.Med.Chem.|11|1709|doi:10.1016/S0968-0896(03)00028-2