Plp38MAPK activity in embryogenesis, morphogenesis and stress response: an indicator of perfect health?

P38 conveys a variety of signals, including conventional growth, migratory and death signals, as well as responding to environmental and mechanical stimuli. These signals induce phosphorylation of p38, which triggers both its translocation to the nucleus and the activation of its catalytic function. In Paracentrotus lividus we have shown that for a correct cilia re-generation the p38 activation is essential; we also showed, by time course Western blotting, two activation peaks during development (morula and early gastrula stages) with a precise localization of activated p38 in micromere and micromere derived cells (Nichel treatment higlighted this feature), and in the oral apical region. Th…