0000000000204902
AUTHOR
Fernando Montero
Historicism: Some Thoughts on Life-World
More than three decades ago, Walter Biemel read a paper at the Third Colloquium of Philosophy at Royaumont on “The Decisive Phases in the Development of Husserl’s Philosophy” that seemed to be definitive.1 Notwithstanding the great value of the facts and reflections that he provided, and the numerous studies devoted afterwards to the same problem, it is not easy to fix different stages in Husserl’s work. This difficulty is increased by the lack of a strict synchrony between the works that Husserl himself published and those that remained unpublished after his death and have been laboriously recovered by his disciples. Actually, in manuscripts belonging to early moments in his life we find t…
Mundo y acción comunicativa según Habermas
La filosofía de la segunda mitad del siglo XX ha adoptado el estilo de los grandes desfiles circenses: Hace pasar ante los ojos atónitos del espectador legiones de autores, montañas de libros y artículos; los agrupa y cataloga, los distribuye en conjuntos que, a su vez, se dividen en otros conjuntos y sobre cada uno de esos grupos coloca sugestivos rótulos. Se despliegan así grandiosas panorámicas, archivos minuciosos en que cada autor, cada teoría quedan clasificados y fichados. Y no cabe duda de que el lector logra con ello un mapa completo de todo cuando ha sucedido en la historia del pensamiento. Pero es dudoso que consiga dilucidar de esta forma el significado de las teorías que han si…
En defensa de la objetividad
El propósito de estas reflexiones es intentar una reposición del lema husserliano «¡a las cosas mismas!» Pero, si a comienzos de siglo esta invocación estaba justificada por el rechazo dcl mentalismo fomentado por los psicologistas, los filósofos del «espíritu» o de la «vida», tal vez por los mismos neokantianos, en nuestro tiempo constituye más bien una reacción contra cierto mentalismo que se ha instalado en la filosofís analítica del lenguaje.
Membrane-Derived Phospholipids Control Synaptic Neurotransmission and Plasticity
Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood. Membrane-derived bioactive phospholipids are potential candidates to control short-term tuning of synaptic signaling, a plastic event essential for information processing at both the cellular and neuronal network levels in the brain. Here, we showed that phospholipids affect excitatory and inhibitory neurotransmission by different degrees, loci, and mechanisms of action. Signaling triggered by lysophosphatidic acid (LPA) evoked rapid and reversible depress…
The Construction of Subjectivity
The doctrinal antagonisms that have appeared in the history of philosophy have often been an expression of tensions existing in those very problems that have generated philosophical thinking. I think that the fundamental task of phenomenology must consist in the clarification of those problems, insofar as they are constituted by strictly phenomenal situations that have provided both the riddles provoking philosophical theories as well as the basic materials for their theoretical construction.
Reduction in the Motoneuron Inhibitory/Excitatory Synaptic Ratio in an Early-Symptomatic Mouse Model of Amyotrophic Lateral Sclerosis
Excitotoxicity is a widely studied mechanism underlying motoneuron degeneration in amyotrophic lateral sclerosis (ALS). Synaptic alterations that produce an imbalance in the ratio of inhibitory/excitatory synapses are expected to promote or protect against motoneuron excitotoxicity. In ALS patients, motoneurons suffer a reduction in their synaptic coverage, as in the transition from the presymptomatic (2-month-old) to early-symptomatic (3-month-old) stage of the hSOD1(G93A) mouse model of familial ALS. Net synapse loss resulted from inhibitory bouton loss and excitatory synapse gain. Furthermore, in 3-month-old transgenic mice, remaining inhibitory but not excitatory boutons attached to mot…