0000000000205512
AUTHOR
Concepción Moreno-iribas
showing 3 related works from this author
Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nest…
2011
The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41,440, 30-69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids were determined at baseline. The APOE polymorphism was sign…
Fitoesteroles plasmáticos: marcadores de una dieta saludable y un riesgo cardiometabólico menor en la población española del estudio EPIC
2009
Resumen Introduccion Las concentraciones elevadas de fitoesteroles plasmaticos, que reflejan una mayor absorcion intestinal de colesterol se han relacionado con un aumento del riesgo cardiovascular. Sin embargo, una situacion de riesgo alto, el sindrome metabolico (SM), se asocia a un aumento de la sintesis y una disminucion de la absorcion de colesterol y, por tanto, a una menor fitoesterolemia. En este estudio hemos investigado la relacion entre los fitoesteroles del plasma y la dieta y la presencia de factores de riesgo cardiovascular, incluidos los componentes del SM. Metodos y resultados En un estudio transversal, se evaluaron la ingesta de fitoesteroles y concentraciones plasmaticas d…
Phytosterol plasma concentrations and coronary heart disease in the prospective Spanish EPIC cohort
2010
Phytosterol intake with natural foods, a measure of healthy dietary choices, increases plasma levels, but increased plasma phytosterols are believed to be a coronary heart disease (CHD) risk factor. To address this paradox, we evaluated baseline risk factors, phytosterol intake, and plasma noncholesterol sterol levels in participants of a case control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort who developed CHD (n = 299) and matched controls (n = 584) who remained free of CHD after a 10 year follow-up. Sitosterol-to-cholesterol ratios increased across tertiles of phytosterol intake (P = 0.026). HDL-cholesterol level increased, …