0000000000206960
AUTHOR
Jun Huang
Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure
Background— Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. Methods and Results— We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensin-converting enzyme inhibitor enalapril (20 mg daily) in 8399 patients with heart failure and reduced ejection fraction in a double-blind trial. The analyses focused on prespecified measures of nonfatal clinical deterioration. In comparison with the enalapril group, fewer LCZ696-treated patients required intensification of med…
Internet of Autonomous Vehicles: Architecture, Features, and Socio-Technological Challenges
Mobility is the backbone of urban life and a vital economic factor in the development of the world. Rapid urbanization and the growth of mega-cities is bringing dramatic changes in the capabilities of vehicles. Innovative solutions like autonomy, electrification, and connectivity are on the horizon. How, then, we can provide ubiquitous connectivity to the legacy and autonomous vehicles? This paper seeks to answer this question by combining recent leaps of innovation in network virtualization with remarkable feats of wireless communications. To do so, this paper proposes a novel paradigm called the Internet of autonomous vehicles (IoAV). We begin painting the picture of IoAV by discussing th…
Multi-hop D2D Communications with Network Coding : From A Performance Perspective
Multi-hop device-to-device (D2D) communications play an important role in expanding D2D coverage. In this paper, we study a relay-based and network-coding-assisted (in particular, XOR coding) multi-hop D2D communication system. In the system, toward jointly considering the impact of interference and network traffic conditions on the quality of D2D communications, various channel fading models and traffic models are investigated, and the packet loss probability of D2D links is meticulously computed using these models. With the packet loss probability of D2D links, the general closed-form expressions of end-to-end packet loss probability (E2EPLP) of the system with the presence (or absence) o…
Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity
Summary Despite development of new antiviral drugs, viral infections are still a major health problem. The most potent antiviral defense mechanism is the innate production of type I interferon (IFN-I), which not only limits virus replication but also promotes antiviral T cell immunity through mechanisms, which remain insufficiently studied. Using the murine lymphocytic choriomeningitis virus model system, we show here that IFN-I signaling on T cells prevented their rapid elimination in vivo. Microarray analyses uncovered that IFN-I triggered the expression of selected inhibitory NK-cell-receptor ligands. Consequently, T cell immunity of IFN-I receptor (IFNAR)-deficient T cells could be rest…
The Monoclonal Antitoxin Antibodies (Actoxumab–Bezlotoxumab) Treatment Facilitates Normalization of the Gut Microbiota of Mice with Clostridium difficile Infection
Antibiotics have significant and long-lasting impacts on the intestinal microbiota and consequently reduce colonization resistance against Clostridium difficile infection (CDI). Standard therapy using antibiotics is associated with a high rate of disease recurrence, highlighting the need for novel treatment strategies that target toxins, the major virulence factors, rather than the organism itself. Human monoclonal antibodies MK-3415A (actoxumab–bezlotoxumab) to C. difficile toxin A and toxin B, as an emerging non-antibiotic approach, significantly reduced the recurrence of CDI in animal models and human clinical trials. Although the main mechanism of protection is through direct neutraliza…