0000000000211241
AUTHOR
Isabel Andujar Perez
Ensuring the Consistency of Biosimilars
Background: Biological products are subject to constant reappraisal by regulatory agencies and pharmaceutical companies once they have entered the market, since every improvement in their manufacturing process has the potential to alter the basic properties of these molecules. Methods: Narrative review focusing on scientific literature as well as legal documents from regulatory agencies. Results: Evaluating the impact of each manufacturing change of these drugs requires rigorous analyses in proportion to the anticipated risk of inducing more or less molecular micro-heterogenicity. There are currently more than 30 biosimilars of TNF-alpha blockers at different stages of testing, each with a …
Conceptos, dimensiones y antecedentes de la confianza en los entornos virtuales
A pesar de la importancia de la generacion de confianza para los gestores de marketing, estudios previos han detectado dificultades para conceptualizar el termino. El presente trabajo tiene como objetivo revisar la literatura en torno al tema con el fin de identificar las contribuciones esenciales sobre el concepto, las dimensiones y los antecedentes de la confianza, proporcionando asi un marco de referencia para futuras investigaciones. Primero se examina la bibliografia relativa al concepto de confianza desde diversas disciplinas. Despues, se analizan las dimensiones de la confianza y sus antecedentes. Mas adelante se centra la atencion en el tratamiento de la confianza en las relaciones …
FRI0662 ACTIVATION AND LEUKOCYTE ADHESION IS ASSOCIATED WITH VASCULAR DAMAGE IN PATIENTS WITH RHEUMATOID ARTHRITIS AND PSORIATIC ARTHRITIS
Background Patients with inflammatory rheumatic diseases, such as rheumatoid arthritis (RA) or psoriatic arthritis (PsA), have a higher cardiovascular risk than the general population. There are data in other pathologies about the role of leukocyte adhesion on endothelial damage. Objectives To evaluate the relationship between leukocyte adhesion and subclinical vascular damage in patients with RA and PsA. Methods Observational, cross-sectional exploratory study. Patients with RA and PsA who had at least one previous vascular study were recruited in a tertiary hospital during a period of 3 months. All of them donated a sample of fresh blood. Neutrophils were isolated and perfused on a monola…