Author: Sieglinde Friebe

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AUTHOR

Sieglinde Friebe

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Regio- and diastereoselective condensation of resorcarenes with primary amines and formaldehyde

1995

Abstract Mannich reactions of resorcarenes 1 with chiral amines yield single diastereomeric tetrakis-(benzodihydro-1,3-oxazine) derivatives 2 in high yields (80–90%). Epimerisation of these products occurs in the presence of acid.

chemistry.chemical_compoundPrimary (chemistry)chemistryYield (chemistry)Organic ChemistryDrug DiscoveryCondensationFormaldehydeDiastereomerOrganic chemistryBiochemistryTetrahedron Letters

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