Regio- and diastereoselective condensation of resorcarenes with primary amines and formaldehyde

6533b7d3fe1ef96bd126121a

RESEARCH PRODUCT

Regio- and diastereoselective condensation of resorcarenes with primary amines and formaldehyde

Volker Böhmer Sabine Gebauer Günter J Krauss Sieglinde Friebe Walter Vogt Ralf Arnecke Iris Thondorf

subject

chemistry.chemical_compound Primary (chemistry)chemistry Yield (chemistry)Organic Chemistry Drug Discovery Condensation Formaldehyde Diastereomer Organic chemistry Biochemistry

description

Abstract Mannich reactions of resorcarenes 1 with chiral amines yield single diastereomeric tetrakis-(benzodihydro-1,3-oxazine) derivatives 2 in high yields (80–90%). Epimerisation of these products occurs in the presence of acid.

year	journal	country	edition	language
1995-08-01	Tetrahedron Letters

https://doi.org/10.1016/0040-4039(95)01267-l

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