0000000000213292

AUTHOR

Isabel Corrales

showing 5 related works from this author

Incidence and dynamics of active cytomegalovirus infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms i…

2014

Single nucleotide polymorphisms (SNPs) in genes involved in the activation or regulation of innate and adaptive immune responses may modulate the susceptibility to and the natural history of certain chronic viral infections. The current study aimed to investigate whether donor and recipient SNPs in the chemokine receptor 5 (rs1800023), monocyte chemoattractant protein 1 (rs13900), interleukin-10 (rs1878672), and Toll-like receptor 9 (rs352140) genes would exert any influence on the rate of incidence and features of CMV DNAemia in the allogeneic stem cell transplantation setting. This was a retrospective observational multicenter study. The cohort consisted of 102 non-consecutive allogeneic …

virus diseasesTLR9Single-nucleotide polymorphismBiologyVirologySNP genotypingTransplantationInterleukin 10Chemokine receptorInfectious DiseasesImmune systemVirologyGenotypeImmunologyJournal of Medical Virology
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Need to evaluate the performance of real-time PCR assays for the quantitation of cytomegalovirus DNA load in lower respiratory tract specimens

2013

There is an increasing appreciation for the potential clinical value of the quantitation of cytomegalovirus (CMV) DNA in the lower respiratory tract in critically ill patients lacking canonical immunosuppression, in view of the possible pathogenic role of CMV in these patients [1]. No data have been published on the analytical performance of real-time PCR assays for this purpose. We present our data on the performance of the COBAS® AmpliPrep/COBAS® TaqMan CMV PCR Assay (Roche Diagnostics, Mannheim, Germany) for the quantitation of CMV DNA in tracheal aspirates (TA). This CMV PCR assay has been approved recently by the US Food and Drug Administration for use with plasma specimens [2]. We cho…

medicine.medical_specialtyLettermedicine.medical_treatmentCongenital cytomegalovirus infectionCytomegalovirusCritical Care and Intensive Care MedicineReal-Time Polymerase Chain ReactionGastroenterologySensitivity and SpecificityCytomegalovirus DNAInternal medicinemedicineTaqManHumansRespiratory Tract InfectionsMechanical ventilationRespiratory tract infectionsbusiness.industryViral Loadmedicine.diseaseVirologyRespiration ArtificialIntensive Care Unitsmedicine.anatomical_structureReal-time polymerase chain reactionCytomegalovirus InfectionsDNA ViralbusinessViral loadRespiratory tract
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Evaluation of the Architect Epstein-Barr Virus (EBV) Viral Capsid Antigen (VCA) IgG, VCA IgM, and EBV Nuclear Antigen 1 IgG Chemiluminescent Immunoas…

2014

ABSTRACTCommercial immunoassays for detecting IgG and IgM antibodies against Epstein-Barr virus (EBV), viral capsid antigens (VCA), and IgGs toward EBV nuclear antigen-1 (EBNA-1) are routinely used in combination to categorize EBV infection status. In this study, we evaluated the performances of the Architect EBV VCA IgG, VCA IgM, and EBNA-1 IgG chemiluminescent microparticle assays (CMIAs) in EBV serological analyses using indirect immunofluorescence assays and anticomplement immunofluorescence assays as the reference methods for VCA IgG, VCA IgM, and EBNA-1 IgG antibody detection, respectively. A total of 365 serum samples representing different EBV serological profiles were included in t…

Microbiology (medical)MaleEpstein-Barr Virus InfectionsHerpesvirus 4 HumanClinical BiochemistryImmunologyFluorescent Antibody Techniquemedicine.disease_causeImmunofluorescenceAntibodies ViralSensitivity and SpecificityImmunoglobulin GSerologyAntigenhemic and lymphatic diseasesDiagnostic Laboratory Immunologyotorhinolaryngologic diseasesImmunology and AllergyMedicineHumansChildAntigens ViralImmunoassaymedicine.diagnostic_testbiologybusiness.industryDiagnostic Tests RoutineInfantVirologyEpstein–Barr virusstomatognathic diseasesEpstein-Barr Virus Nuclear AntigensImmunoglobulin MImmunoglobulin MImmunoassayChild PreschoolImmunoglobulin GImmunologyLuminescent Measurementsbiology.proteinCapsid ProteinsFemaleAntibodybusiness
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Epidemiology of invasive candidiasis in a surgical intensive care unit: an observational study

2015

Background: Invasive candidiasis (IC) is a frequent and life-threatening infection in critically ill patients. The aim of this study was to evaluate the epidemiology of IC and the antifungal susceptibility of etiological agents in patients admitted to our surgical intensive care unit (SICU) in Spain. Methods: We designed a prospective, observational, single center, population-based study in a SICU. We included all consecutive adult patients (≥18 years old) who had documented IC, either on admission or during their stay, between January 2012 and December 2013. Results: There were a total of 22 episodes of IC in the 1149 patients admitted during the 24-month study. The overall IC incidence wa…

Malemedicine.medical_specialtyAntifungal AgentsPopulationMicrobiologiaMicrobial Sensitivity TestsCandida parapsilosisGeneral Biochemistry Genetics and Molecular Biologylaw.inventionCandida tropicalisDrug Resistance FungallawInternal medicineCandida kruseiAbdomenmedicineHumansSurgical Wound InfectionIntensive care unitCandidiasis InvasiveCandida albicanseducationEpidemiologiaAgedCandidaMedicine(all)education.field_of_studyCandida glabratabiologybusiness.industryBiochemistry Genetics and Molecular Biology(all)CandidemiaGeneral MedicineFongs patògensMiddle Agedbiology.organism_classificationIntensive care unitSurgeryInvasive candidiasisIntensive Care UnitsTreatment OutcomeSpainFemalebusinessAntifungal susceptibilitySurgery Department HospitalFluconazoleResearch Articlemedicine.drugBMC Research Notes
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Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant …

2013

The current study was aimed at investigating whether the single nucleotide polymorphism (SNP) (rs12979860), upstream of the IL28B gene, had any effect on the incidence rate and the features of active CMV infection in the Allogeneic stem cell transplantation setting. This was a retrospective observational study including 151 patients undergoing T cell-replete Allo-SCT. Donor and recipient IL28 SNP genotype was determined by allele-specific real-time PCR. The incidence rate of active CMV infection was not significantly associated with either the donor or the recipient IL28B SNP genotype. Nevertheless, a trend towards a lower incidence of active CMV infection was noted in the donor T/T populat…

education.field_of_studyIncidence (epidemiology)PopulationSingle-nucleotide polymorphismBiologyVirologyTransplantationInfectious DiseasesPolymorphism (computer science)VirologyImmunologyGenetic modelGenotypeAlleleeducationJournal of Medical Virology
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