Test de la sacarina en el estudio del aclaramiento mucociliar. Valores de referencia en una población española

Objetivo El transporte mucociliar es un importante mecanismo de defensa de las vias respiratorias. El objetivo de este estudio ha sido obtener los valores de referencia del tiempo de transporte mucociliar nasal (TTMCN) mediante el test de la sacarina. Sujetos y metodos Se ha realizado un estudio observacional, transversal y descriptivo. Las variables estudiadas fueron el TTMCN, la edad y el sexo. Se incluyo a 249 sujetos (134 varones y 115 mujeres) mayores de 10 anos, sanos y no fumadores, que se asignaron a grupos segun su edad. Para el analisis predictivo de los valores de normalidad se obtuvieron los percentiles, estableciendo los limites de referencia por los percentiles 2,5 y 97,5. Se …

Síndrome hepatopulmonar en paciente con adenocarcinoma de colon con metástasis hepáticas y sin hepatopatía crónica conocida

El sindrome hepatopulmonar comprende una triada clinica caracterizada por desoxigenacion arterial, dilataciones vasculares intrapulmonares y hepatopatia. Se han descrito tanto casos agudos como cronicos, y la causa mas frecuente es la cirrosis. El mecanismo fisiopatologico principal es la dilatacion de los vasos pulmonares, que produce una alteracion del intercambio gaseoso. Se ha implicado la mayor produccion pulmonar de oxido nitrico como mecanismo patogenico principal de la vasodilatacion, aunque tambien se ha relacionado el desequilibrio entre sustancias vasodilatadoras y vasoconstrictoras. Describimos un caso en el que se produjo un sindrome hepatopulmonar en un paciente afectado de un…

[Saccharin test for the study of mucociliary clearance: reference values for a Spanish population].

Objective Mucociliary transport is an important defense mechanism for the airways. The aim of this study was to establish reference values for nasal mucociliary clearance time (MCT) by means of the saccharin test. Subjects and Methods A cross-sectional, descriptive, observational study was performed. The variables studied were nasal MCT, age, and sex. We included 249 healthy nonsmokers (134 male and 115 female subjects) aged over 10 years and stratified the sample by age. To establish reference values, percentiles were calculated and lower and upper limits of normal were established at the 2.5 and 97.5 percentiles, respectively. The association between nasal MCT and the main study variables…

Hepatopulmonary Syndrome in a Patient With Adenocarcinoma of the Colon Metastatic to the Liver and No Apparent Chronic Liver Disease

Hepatopulmonary syndrome consists of a clinical triad: arterial blood deoxygenation, intrapulmonary vasodilation, and liver disease. Both acute and chronic cases of this syndrome have been reported, and the most common cause is cirrhosis. The principle disease mechanism is dilation of the pulmonary blood vessels causing alterations in gas exchange. Increased pulmonary production of nitric acid has been implicated as the primary pathogenic mechanism of vasodilation although it has also been associated with imbalance between vasodilators and vasoconstrictors. We describe the case of a patient with hepatopulmonary syndrome and adenocarcinoma of the colon with metastases to a previously healthy…

Long-Term Oxygen Therapy