0000000000214708
AUTHOR
Carolin Brandscheid
Oxidative (Cross-)Coupling Reactions Mediated by C-H Activation of Thiophene Derivatives by Using Molybdenum(V) Reagents
Oxidative coupling by using molybdenum pentachloride provides fast and modular access to sophisticated thienoacenes in excellent yields. The coupling process can be accomplished with thiophene and benzothiophene derivatives and provides various complex skeletons such as spirocyclic compounds. In this approach, the first cross-coupling reactions with the use of MoCl5 were established and important motifs for semiconducting materials were synthesized.
ChemInform Abstract: Oxidative (Cross-)Coupling Reactions Mediated by C-H Activation of Thiophene Derivatives by Using Molybdenum(V) Reagents.
The use of MoCl5 renders possible the preparation of various synthetically important polycyclic thienoacenes.
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.
The regulation of physiological gut functions such as peristalsis or secretion of digestive enzymes by the central nervous system via the Nervus vagus is well known. Recent investigations highlight that pathological conditions of neurological or psychiatric disorders might directly interfere with the autonomous neuronal network of the gut - the enteric nervous system, or even derive from there. By using a murine Alzheimer's disease model, we investigated a potential influence of disease-associated changes on gastrointestinal properties. 5xFAD mice at three different ages were compared to wild type littermates in regard to metabolic parameters and enzymes of the gut by fluorimetric enzyme as…