0000000000214977
AUTHOR
Srinivas Banala
Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers
Riboflavin transporters (RFTs) and the riboflavin carrier protein (RCP) are highly upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes them attractive targets for nanomedicines. Addressing cells in different tumor compartments requires drug carriers, which are not only able to accumulate via the EPR effect but also to extravasate, target specific cell populations, and get internalized by cells. Reasoning that antibodies are among the most efficient targeting systems developed by nature, we consider their size (-10-15 nm) to be ideal for balancing passive and active tumor targeting. Therefore, small, short-circulating (10 kDa, -7 nm, t1/2 - 1 h) and large…
Additional file 1 of Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance
Additional file 1: Figure S1. Zeta potential analysis of the crude, C1-C5, Resovist® and Sinerem® samples. Figure S2. Cell viability of NIH3T3 cells treated with the samples with various concentrations ofSPION for 4 h according to XTT assay. The data were normalized to control value (SPION-freemedia), which was set as 100% cell viability. Experiments were performed at different concentrationsof SPION in the range of 0.1 to 10.0 mM. Values represent means ± standard deviations of fiveidentical experiments made in three replicates. Figure S3. LDH leakage of NIH3T3 cells treated with the samples with various concentrations ofSPION for 4 h according to the manufacturer’s instructions. Experimen…
Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance.
Journal of nanobiotechnology 18, 22 (2020). doi:10.1186/s12951-020-0580-1