0000000000214977

AUTHOR

Srinivas Banala

showing 3 related works from this author

Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers

2017

Riboflavin transporters (RFTs) and the riboflavin carrier protein (RCP) are highly upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes them attractive targets for nanomedicines. Addressing cells in different tumor compartments requires drug carriers, which are not only able to accumulate via the EPR effect but also to extravasate, target specific cell populations, and get internalized by cells. Reasoning that antibodies are among the most efficient targeting systems developed by nature, we consider their size (-10-15 nm) to be ideal for balancing passive and active tumor targeting. Therefore, small, short-circulating (10 kDa, -7 nm, t1/2 - 1 h) and large…

MaleBiodistributionMaterials scienceCell SurvivalPolymersSurface PropertiesRiboflavinBioengineering02 engineering and technology010402 general chemistry01 natural sciencesPolyethylene GlycolsMiceProstate cancerDownregulation and upregulationRiboflavin-carrier proteinCell Line TumorPEG ratiomedicineAnimalsHumansTissue DistributionGeneral Materials ScienceParticle Sizepassive and active tumor targetingCell ProliferationDrug CarriersbiologyMechanical EngineeringMembrane Transport ProteinsProstatic NeoplasmsTransporterGeneral Chemistry021001 nanoscience & nanotechnologyCondensed Matter Physicsmedicine.diseasen/a OA procedure0104 chemical sciencesCell biologybranched PEGBiochemistrybiology.proteinHeterograftsAntibody0210 nano-technologyDrug carrierNano Letters
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Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance.

2020

Journal of nanobiotechnology 18, 22 (2020). doi:10.1186/s12951-020-0580-1

Hyperthermialcsh:Medical technologyMaterials sciencelcsh:BiotechnologyDispersityBiomedical EngineeringIron oxidePharmaceutical ScienceMedicine (miscellaneous)NanoparticleContrast MediaBioengineering02 engineering and technology010402 general chemistry01 natural sciencesApplied Microbiology and BiotechnologyTheranostic Nanomedicinechemistry.chemical_compoundStructure-Activity RelationshipIron oxide nanoparticlesMagnetic particle imagingDynamic light scatteringlcsh:TP248.13-248.65medicineHumansHyperthermiaParticle SizeMagnetite Nanoparticlesmedicine.diagnostic_testResearchSPIONMagnetic resonance imagingDextransHyperthermia Induced021001 nanoscience & nanotechnologymedicine.diseaseImage EnhancementMagnetic Resonance Imaging0104 chemical scienceslcsh:R855-855.5chemistryMolecular MedicineMPI0210 nano-technologyIron oxide nanoparticlesBiomedical engineeringMRIJournal of nanobiotechnology
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Additional file 1 of Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance

2020

Additional file 1: Figure S1. Zeta potential analysis of the crude, C1-C5, Resovist® and Sinerem® samples. Figure S2. Cell viability of NIH3T3 cells treated with the samples with various concentrations ofSPION for 4 h according to XTT assay. The data were normalized to control value (SPION-freemedia), which was set as 100% cell viability. Experiments were performed at different concentrationsof SPION in the range of 0.1 to 10.0 mM. Values represent means ± standard deviations of fiveidentical experiments made in three replicates. Figure S3. LDH leakage of NIH3T3 cells treated with the samples with various concentrations ofSPION for 4 h according to the manufacturer’s instructions. Experimen…

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