0000000000215528

AUTHOR

M Benet

showing 5 related works from this author

Pharmacokinetics of oligodeoxynucleotides encapsulated in liposomes: effect of lipid composition and preparation method

2000

1. The effect of the method employed to prepare liposomes and their lipid composition were evaluated in terms of the encapsulation efficiency and pharmacokinetic features of two oligodeoxynucleotides of a 21 mer: the normal (N-Odn) and the phosphorothioate (S-Odn) oligodeoxynucleotide. 2. Liposomes were prepared by the classical method of multilamellar vesicles (MV) and by the dehydration-rehydration method (DR). Two lipid mixtures were used to prepare liposomes--the predominant lipid being phosphatidylcholine (PC) and sphingomyelin (SM) respectively. 3. The DR method for liposome preparation provided the highest encapsulation efficiency, regardless of liposome lipid composition and the typ…

Drug CompoundingHealth Toxicology and MutagenesisLipid compositionMultilamellar vesiclesToxicologyBiochemistryPreparation methodMicechemistry.chemical_compoundPharmacokineticsPhosphatidylcholineAnimalsPharmacologyPlasma clearanceLiposomeChromatographyChemistryhemic and immune systemsGeneral MedicineThionucleotidesrespiratory systemLipidsOligodeoxyribonucleotidesBiochemistryInjections IntravenousLiposomesSphingomyelinXenobiotica
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Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representat…

2021

Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prev…

MaleLatin AmericansNutrition and DiseaseEpidemiology[SDV]Life Sciences [q-bio]MedizinBLOOD-PRESSURE030204 cardiovascular system & hematologyWorldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.Hypertension ; Prevalence ; Control ; TretamentGUIDELINESGlobal HealthWorldwide trends0302 clinical medicineHypertension prevalenceVoeding en ZiekteMedicine and Health Scienceskohonnut verenpainePrevalenceMedicine030212 general & internal medicinePrevention and Control11 Medical and Health SciencesComputingMilieux_MISCELLANEOUSHypertension prevalenceeducation.field_of_studyfood and beveragesPublic Health Global Health Social Medicine and EpidemiologyGeneral MedicineNoncommunicable diseases; Hypertension; Period prevalenceMiddle Agedkansainvälinen vertailu3142 Public health care science environmental and occupational health3. Good healthMIDDLE-INCOMEPooled analysisBLOOD-PRESSURE; SYSTEMATIC ANALYSIS; INCOME COUNTRIES; MIDDLE-INCOME;ADULTS;PREVENTION;GUIDELINES;MANAGEMENT;ADHERENCE;DIAGNOSISWestern europeHypertension[SDE]Environmental SciencesHypertension/diagnosisNCD Risk Factor Collaboration (NCD-RisC)FemaleB990 Subjects Allied to Medicine not elsewhere classifiedLife Sciences & BiomedicineAdulthealth-careesiintyvyysCentral asiaPopulationNursing.3121 Internal medicineDIAGNOSIS03 medical and health sciencesMedicine General & InternalADHERENCEDrug TherapyGeneral & Internal MedicineControlMANAGEMENTSYSTEMATIC ANALYSISLife ScienceHumansddc:610INCOME COUNTRIESeducationAntihypertensive AgentsVLAGAgedScience & TechnologyAntihypertensive Agents/therapeutic usebusiness.industryOmvårdnadfungiGeneral and internal medicineADULTSEstados de Saúde e de DoençaPREVENTIONTaking medicationTreatmentFolkhälsovetenskap global hälsa socialmedicin och epidemiologiBlood pressureFaculdade de Ciências Sociais3121 General medicine internal medicine and other clinical medicinelääkehoito1182 Biochemistry cell and molecular biologybusinessDemography
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Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants

2016

Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis w…

MaleBlood GlucoseAdultResearch ReportSettore MED/09 - Medicina Internaglucosa sanguíneaEpidemiologyhumanosEpidemiology; prevention; public health; diabetescoste de las enfermedadesDiabetes epidemiologyGlobal HealthincidenciaWorldwide trendsdistribución por sexosAge DistributionSDG 3 - Good Health and Well-beingCost of Illnessdistribución por edadespreventionpaíses en desarrolloDiabetes MellitusPrevalenceInsulinHumansHypoglycemic AgentsinsulinaAge of OnsetSex DistributionDeveloping CountriesdiabetesVDP::Medical disciplines: 700::Clinical medical disciplines: 750Incidenceprevalenciapublic healthVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750Bayes TheoremadultoHealth Surveysinforme de investigación//purl.org/pe-repo/ocde/ford#3.02.00 [https]hipoglicemiantesencuestas de saludFemalepooled analysisteorema de Bayes
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

2017

Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of rai…

presión sanguíneahypertensionSettore MED/09 - Medicina Internaunited-stateshumanosBlood Pressuresystematic analysisGlobal HealthRisk FactorsGeneral & Internal MedicinePrevalencefactores de riesgoHumanssecular trendscardiovascular risk-factorsMedicine (all)global burdenprevalenciaBayes Theoremgender-differences//purl.org/pe-repo/ocde/ford#3.02.00 [https]sodium-intakehealth examination surveyslow-incometeorema de Bayes
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Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU…

2016

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sen…

asthma; IgE; multimorbidity; polysensitization; rhinitis.
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