0000000000218352
AUTHOR
Ji-youn Han
showing 4 related works from this author
Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Cl…
2017
AbstractPurpose: This study investigated the safety, clinical activity, and target-associated biomarkers of lumretuzumab, a humanized, glycoengineered, anti-HER3 monoclonal antibody (mAb), in combination with the EGFR-blocking agents erlotinib or cetuximab in patients with advanced HER3-positive carcinomas.Experimental Design: The study included two parts: dose escalation and dose extension phases with lumretuzumab in combination with either cetuximab or erlotinib, respectively. In both parts, patients received lumretuzumab doses from 400 to 2,000 mg plus cetuximab or erlotinib according to standard posology, respectively. The effect of HRG mRNA and HER3 mRNA and protein expression were inv…
Correlations between isospin dynamics and Intermediate Mass Fragments emission time scales: a probe for the symmetry energy in asymmetric nuclear mat…
2012
We show new data from the $^{64}$Ni+$^{124}$Sn and $^{58}$Ni+$^{112}$Sn reactions studied in direct kinematics with the CHIMERA detector at INFN-LNS and compared with the reverse kinematics reactions at the same incident beam energy (35 A MeV). Analyzing the data with the method of relative velocity correlations, fragments coming from statistical decay of an excited projectile-like (PLF) or target-like (TLF) fragments are discriminated from the ones coming from dynamical emission in the early stages of the reaction. By comparing data of the reverse kinematics experiment with a stochastic mean field (SMF) + GEMINI calculations our results show that observables from neck fragmentation mechani…
N/Z effects on evaporation residue emission near fragmentation threshold
2011
We will discuss results concerning the fate of hot nuclear systems populated in 40,48 Ca+ 40,48 Ca reactions at 25 MeV/nucleon. Due to the complexity of events, we used the Chimera 4π device as detection system. By selecting central events of reaction, we found that the interplay between binary-like and evaporation residue emissions is strongly sensitive on the N/Z of the entrance channels. In particular, evaporation residue emission increases at increasing the neutron content of colliding system. By comparing or data with CoMD-II model calculations, we can extract information about the density depend part of Symmetry Potential in the Nuclear Equation of State at near-saturation densities.
N/Z effects on40,48Ca+40,48Ca reactions at 25 MeV/nucleon
2012
Effects related to the neutron to proton ratio (N/Z) degree of freedom in 40, 48Ca+40, 48Ca reactions at 25 MeV/nucleon have been investigated. Isotopic effect and even-odd staggering characterize the emission of light fragments at forward angles. The study of isobaric ratio 7Li/7Be for quasi-projectile source in semi-peripheral event of reactions allows moreover to investigate isospin diffusion effects in heavy ion collisions. © Owned by the authors, 2012.