The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.

Item does not contain fulltext Plasma triglyceride concentration is a biomarker for circulating triglyceride-rich lipoproteins and their metabolic remnants. Common mild-to-moderate hypertriglyceridaemia is typically multigenic, and results from the cumulative burden of common and rare variants in more than 30 genes, as quantified by genetic risk scores. Rare autosomal recessive monogenic hypertriglyceridaemia can result from large-effect mutations in six different genes. Hypertriglyceridaemia is exacerbated by non-genetic factors. On the basis of recent genetic data, we redefine the disorder into two states: severe (triglyceride concentration >10 mmol/L), which is more likely to have a mono…

Enregistrement du cycle du carbone au Pliensbachien (Jurassique inférieur) sur la marge sud téthysienne (Amellago, Haut-Atlas Central, Maroc)

International audience; Le Pliensbachien s’inscrit dans un contexte climatique greenhouse au Jurassique, en période de dislocation de la Pangée. De récentes études dans le domaine nord-ouest téthysien ont démontré une certaine variabilité climatique soutenue notamment par des variations isotopiques remarquables dans le cycle du carbone, comparables en amplitude et en durée à d’autres événements du Toarcien (e.g. T-OAE). Malgré la multiplication des travaux le long de la marge nord téthysienne avec la mise en évidence de changements géodynamiques importants, la marge sud n’a jamais été étudiée à haute résolution. Nous proposons, dans un cadre biostratigraphique extrêmement précis (ammonites …

Breakfast consumption and its socio-demographic and lifestyle correlates in schoolchildren in 41 countries participating in the HBSC study

Objective: To investigate associations of daily breakfast consumption (DBC) with demographic and lifestyle factors in 41 countries. Methods: Design: Survey including nationally representative samples of 11–15 year olds (n = 204,534) (HBSC 2005–2006). Statistics: Multilevel logistic regression analyses Results: DBC varied from 33 % (Greek girls) to 75 % (Portuguese boys). In most countries, lower DBC was noticed in girls, older adolescents, those with lower family affluence and those living in single-parent families. DBC was positively associated with healthy lifestyle behaviours and negatively with unhealthy lifestyle behaviours. peerReviewed

GRB 101225A - an unusual stellar death on Christmas Day

Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes

Item does not contain fulltext BACKGROUND: Although P2Y12 antagonists are effective in patients with non-ST-segment elevation (NSTE) acute coronary syndromes, the effect of the timing of administration--before or after coronary angiography--is not known. We evaluated the effect of administering the P2Y12 antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention (PCI) was indicated. METHODS: We enrolled 4033 patients with NSTE acute coronary syndromes and a positive troponin level who were scheduled to undergo coronary angiography within 2 to 48 hours after randomization. Patients were randomly assigned to recei…

Le gisement pléistocène moyen récent de Romain-la-Roche (Doubs, France) : synthèse biostratigraphique et paléoécologique

Accessible à l'adresse : http://www.ville-ge.ch/mhng/paleo/paleo-pdf/29-2/pal_29_2_07_20.pdf; International audience; L'aven de Romain-la-Roche est une cavité karstique ayant fonctionné comme un piège naturel dans lequel sont tombés de nombreux grands animaux, et où divers petits vertébrés ont été amenés en tant que proies d'oiseaux rapaces. Le gisement a été fouillé de 1980 à 1991 par Patrick Paupe et son équipe, qui y a recueilli 52 espèces de mammifères (plus de 10 000 restes déterminables), au moins 13 espèces d'oiseaux, deux de reptiles, une d'amphibien, deux espèces de poissons et des gastéropodes indéterminés. Les espèces de mammifères présentes sont pour 34,6 % des rongeurs (3975 re…

MALIGNANT NON-SEMINOMATOUS GERM CELL TUMORS (MNSGCT) IN CHILDREN: Results of a Study of Italian Association Pediatric Oncology (AIEOP).

The authors report the results of the Italian study on the treatment of non-seminomatous germ cell tumors in pediatric age and present the results of the diagnostic and therapeutic process in their experience

Entropy Flux in Non-Equilibrium Thermodynamics

Evidence of an Early Triassic age (Olenekian) in Argana Basin (High Atlas, Morocco) based on new chirotherioid traces

National audience

The transient gravitational-wave sky

Reconstitutions paléoenvironnementales et enregistrement paléoclimatique fini-carbonifère à permien du bassin d’Autun (Nord-Est du Massif Central)

International audience; Les bassins sédimentaires tardi-orogéniques fini-carbonifères à permiens du Nord-Est du Massif Central (bassins d’Autun, de l’Aumance, de Decize-La Machine et de Blanzy-Le Creusot) ont été principalement étudiés pour leur potentiel en ressources carbonées jusque dans les années 1980. Le regain d’intérêt qu’ils suscitent aujourd’hui s’appuie sur des aspects plus fondamentaux afin de mieux comprendre la période charnière qu’est la fin du Paléozoïque. Les séries sédimentaires préservées dans ces bassins continentaux enregistrent en effet le démantèlement des reliefs hercyniens ainsi que l’évolution climatique (transition icehouse-greenhouse) se produisant entre la fin d…

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

AbstractThe STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes. The co-primary endpoints were the percentage change in body weight and achievement of weight loss of ≥5% at week 104. Efficacy was assessed among all randomized participants regardless of treatment discontinuation or rescue intervention. From 5 October 2018 to 1 February 2019, 304 participants were randomly assigned to semaglutide 2.4 mg (n = 152) or placebo (n = 152), 92.8% of whom completed the trial (attended t…

Produzione e scienza del progetto nella ricerca e nella didattica del Dottorato in Progettazione Architettonica (XVI CICLO)

Testo in cui vengono esposti modi e ragioni della “scienza del progetto”, ricerca del Dottorato in Progettazione di Pasquale Culotta, elaborato con T. Aglieri Rinella, A. De Fazio, I. Lodato, V. Santangelo, G. Smeriglio.

Distribution of maternity units and spatial access to specialised care for women delivering before 32 weeks of gestation in Europe

Contains fulltext : 88841.pdf (Publisher’s version ) (Closed access) Survival and quality of life are improved for very preterm babies when delivery occurs in a maternity unit with on-site neonatal intensive care (level III unit). We investigated the impact of distance on the probability of delivering in such a unit for births before 32 weeks of gestation from 9 European regions with diverse perinatal health systems (the MOSAIC cohort). We analysed distances between women's homes, and the nearest level III in population quartiles, adjusting for maternal and pregnancy characteristics. Living farther away from a level III reduced access to specialised care everywhere; in some regions women re…

EURECCA colorectal: multidisciplinary mission statement on better care for patients with colon and rectal cancer in Europe

Contains fulltext : 125368.pdf (Publisher’s version ) (Closed access) BACKGROUND: Care for patients with colon and rectal cancer has improved in the last twenty years however still considerable variation exists in cancer management and outcome between European countries. Therefore, EURECCA, which is the acronym of European Registration of cancer care, is aiming at defining core treatment strategies and developing a European audit structure in order to improve the quality of care for all patients with colon and rectal cancer. In December 2012 the first multidisciplinary consensus conference about colon and rectum was held looking for multidisciplinary consensus. The expert panel consisted of…

Method and apparatus using selected superparamagnetic labels for rapid quantification of immunochromatographic tests

Mika PA Laitinen1, Jari Salmela2, Leona Gilbert1, Risto Kaivola1, Topi Tikkala2, Christian Oker-Blom1, Jukka Pekola3, Matti Vuento11Department of Biological and Environmental Science; 2Department of Physics, University of Jyväskylä, Jyväskylä, Finland; 3Low Temperature Laboratory, Helsinki University of Technology, Helsinki, FinlandAbstract: A rapid method and instrumentation for quantification of immunochromatographic tests (ICT) are described. The principle and performance of the method was demonstrated by measuring the levels of human chorionic gonadotropin (hCG) present in urine. The test format was a sandwich assay using two distinct monoclonal antib…

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

Contains fulltext : 118365.pdf (Publisher’s version ) (Closed access) BACKGROUND: Until now, only imatinib and sunitinib have proven clinical benefit in patients with gastrointestinal stromal tumours (GIST), but almost all metastatic GIST eventually develop resistance to these agents, resulting in fatal disease progression. We aimed to assess efficacy and safety of regorafenib in patients with metastatic or unresectable GIST progressing after failure of at least imatinib and sunitinib. METHODS: We did this phase 3 trial at 57 hospitals in 17 countries. Patients with histologically confirmed, metastatic or unresectable GIST, with failure of at least previous imatinib and sunitinib were rando…

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

The Global Burden of Diseases, Injuries and Risk Factors 2017 includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include incr…

Breast-cancer predisposition in multiple endocrine neoplasia type 1

Women with multiple endocrine neoplasia type 1 related to mutations in the gene encoding menin (MEN1) have approximately twice the risk of breast cancer as do women in the general population.

Secondo seminario Città e campagne del Ticino. Progetto per Vigevano città sul fiume

Il progetto della stazione dell’alta velocità di Vigevano in un workshop internazionale di tre settimane, elaborato con T. Aglieri Rinella, R. Canella, A. De Fazio, D. Derossi, F. Fagnano, F. Lambertucci.