6533b873fe1ef96bd12d4f22

RESEARCH PRODUCT

Breast-cancer predisposition in multiple endocrine neoplasia type 1

K.m. DreijerinkP. GoudetJ.r. BurgessG.d. ValkE.b. ConemansC. CornelissenM. Van BloklandM. MannstadtC.r. PietermanC. BinquetO.m. DekkersM.l. DrentA.n. Van Der Horst-schriversW.w. De HerderB. HavekesE. FliersA.r. HermusM.r. VriensEt Al.

subject

OncologyAdultRiskcongenital hereditary and neonatal diseases and abnormalitiesendocrine systemmedicine.medical_specialtyendocrine system diseasesGenotypePopulationVascular damage Radboud Institute for Health Sciences [Radboudumc 16]Breast Neoplasmsmedicine.disease_causeArticleBreast cancerSDG 3 - Good Health and Well-beingInternal medicineProto-Oncogene ProteinsGenotypemedicineCarcinomaMultiple Endocrine Neoplasia Type 1HumansMEN1Genetic Predisposition to DiseaseLongitudinal StudiesMultiple endocrine neoplasiaeducationGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)GeneNetherlandsMutationeducation.field_of_studybusiness.industryCarcinoma Ductal BreastGeneral MedicineMiddle Agedmedicine.diseaseCarcinoma PapillaryImmunologyMutationFemalebusiness

description

Women with multiple endocrine neoplasia type 1 related to mutations in the gene encoding menin (MEN1) have approximately twice the risk of breast cancer as do women in the general population.

yearjournalcountryeditionlanguage
2014-08-07
10.1056/nejmc1406028https://research.vumc.nl/en/publications/69e3b32c-aa79-4dd7-a4c5-8ec062a50d9f