0000000000218424

AUTHOR

Angela Gomes

showing 4 related works from this author

WITHDRAWN: Systems Biology and Immune Aging

2014

The Publisher regrets that this article is an accidental duplication of anarticle that has already been published, http://dx.doi.org/10.1016/j.imlet.2014.09.009 . The duplicate article has therefore been withdrawn.

Immune systembusiness.industryAccidentalSystems biologyImmunologyGene duplicationImmunology and AllergyMedicineBioinformaticsbusinessImmunology Letters
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Oxidative imbalance in low/intermediate-1-risk myelodysplastic syndrome patients: The influence of iron overload

2017

Abstract Objective To assess the generation of reactive oxygen species (ROS) and the involvement of the main antioxidant pathways in low/intermediate-1-risk myelodysplastic syndromes (MDS) with iron overload (IOL). Methods We examined the levels of superoxide anion (O2 −), hydrogen peroxide (H2O2), antioxidants (glutathione, GSH; superoxide dismutase, SOD; catalase, CAT; and glutathione peroxidase, GPx), mitochondrial membrane potential (ΔΨm), and by-products of oxidative damage (8-isoprostanes and 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-dG) in 42 MDS patients (28 without IOL at diagnosis, and 14 who developed IOL) and 20 healthy subjects. Results Patients with IOL showed higher O2 − lev…

Male0301 basic medicinemedicine.medical_specialtyIron OverloadAntioxidantmedicine.medical_treatmentClinical Biochemistrymedicine.disease_causeAntioxidantsSuperoxide dismutase03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicinemedicineHumansAgedAged 80 and overchemistry.chemical_classificationGlutathione PeroxidaseReactive oxygen speciesbiologySuperoxideGlutathione peroxidaseGeneral MedicineGlutathioneCatalaseOxidative Stress030104 developmental biologyEndocrinologychemistryBiochemistryCatalaseMyelodysplastic Syndromes030220 oncology & carcinogenesisbiology.proteinFemaleOxidative stressClinical Biochemistry
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Systems Biology and immune aging

2014

Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a given biological system. Systems Biology benefits from the continuous advances in the omics sciences, based on high-throughput and high-content technologies, as well as on bioinformatic tools for data mining and integration. The Systems Biology approach is becoming gradually used to propose and to test comprehensive models of aging, both at the level of the immune system and the wh…

ProteomicsAgingBioinformaticsmedia_common.quotation_subjectSystems biologyImmunologyLongevityContext (language use)GenomicsBiologyBioinformaticsImmune systemCytomicsHumansImmunology and AllergyMetabolomicsmedia_commonSystems immunologyCognitive scienceSystems BiologyImmunityLongevityImmunosenescenceGenomicsbiochemical phenomena metabolism and nutritionAcquired immune systembacteria
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Real-time cytometric assay of nitric oxide and superoxide interaction in peripheral blood monocytes: A no-wash, no-lyse kinetic method

2015

Background Nitric oxide (NO) and its related reactive nitrogen species (RNS) and reactive oxygen species (ROS) are crucial in monocyte responses against pathogens and also in inflammatory conditions. Central to both processes is the generation of the strong oxidant peroxynitrite (ONOO) by a fast reaction between NO and superoxide anion. ONOO is a biochemical junction for ROS- and RNS cytotoxicity and causes protein nitrosylation. Circulating by-products of protein nitrosylation are early biomarkers of inflammation-based conditions, including minimal hepatic encephalopathy in cirrhotic patients (Montoliu et al., Am J Gastroenterol 2011; 106:1629–1637). In this context, we have designed a nov…

0301 basic medicinechemistry.chemical_classificationReactive oxygen speciesHistologymedicine.diagnostic_testProtein nitrosylationSuperoxideContext (language use)Cell BiologyMolecular biologyPathology and Forensic MedicineNitric oxideFlow cytometry03 medical and health scienceschemistry.chemical_compound030104 developmental biologychemistryBiochemistrymedicinePeroxynitriteReactive nitrogen speciesCytometry Part B: Clinical Cytometry
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