0000000000222197
AUTHOR
V. Kovanen
The effects of immobilization on the quality of Achilles tendon in rats
Immobilization of an Achilles tendon in a shortened position for 1 and 3 weeks did not change pyridinoline and mature collagen concentrations. Although a significant decrease in the biosynthesis of collagen was observed simultaneously in the soleus muscle of the same hindlimb, these results suggest that the stability of collagen provided by the nonreducible cross-link, pyridinoline, is not altered during this type of immobilization. The significance of stable cross-links for the known decrease in tensile strength during immobilization remains open.
Collagens in the injured porcine intervertebral disc
Spinal pain often is thought to be due to degeneration and mechanical failure of the intervertebral disc. Since the mechanical strength of the tissue depends on collagen fibers, the present study was designed to investigate the reactions in collagen metabolism after an experimentally induced disc injury. Five domestic pigs underwent an incision in the anterior part of the annulus fibrosus of disc L4-L5 through a retroperitoneal approach. The animals were killed 3 months postoperatively, and the injured discs and intact discs (controls) from different animals were removed for chemical analysis. Slices were cut from seven different parts across the disc. The concentration of total collagen (h…
Serum and urine markers of type I collagen metabolism in elderly women with high and low bone mineral density.
The serum markers of bone formation (carboxy-terminal propeptide of type I collagen, PICP) and resorption (pyridinoline cross-links containing telopeptide of type I collagen, ICTP), as well as urinary resorption markers, pyridinoline (Pyr) and deoxypyridinoline (Dpyr), were studied in 78-year-old women with high (n = 18) and low (n = 17) bone mineral density (BMD) measured from the calcaneus and tibia. The low-BMD group had higher values for PICP (P = 0 center dot 025), Pyr (P = 0 center dot 001) and Dpyr (P < 0 center dot 001) than the high-BMD group. No inverse relationship between these markers and BMD was, however, observed within the study groups. ICTP, Pyr and Dpyr correlated with eac…