Effectiveness of Safety Warnings in Atypical Antipsychotic Drugs
Studies conducted to obtain drug authorization are often of short duration and based on small sample sizes in selected populations. Policies on drug safety rely on the validity of the methods used to achieve rapid and effective communication of new information. No formal evaluation has ever been made of the Spanish communications system, although indirect data have raised questions about its effectiveness.To evaluate the impact of two safety warnings issued by the Spanish Drug Agency, and of a later prior authorization requirement involving the use of atypical antipsychotic drugs in the elderly.The study was based on a time-series analysis constructed with data corresponding to monthly invo…
Composition of the Essential Oil ofDictamnus hispanicusfrom Spain
The composition of the essential oil of Dictamnus hispanicus Webb ex. Willk. collected in eastern Spain was analyzed by GC and GC/MS. The main constituents identified were methyl chavicol (79%) and limonene (7%). The high oil yield (72.0% fresh plant material) and the proportion of the main compounds support the consideration of D. hispanicus as a separate species of the S. and CS. Europe as D. albus aggregate or as a new chemotype of the polymorphic D. albus.
Differential essential oil composition and morphology between perennial satureja species growing in Spain
Chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of thirty six samples of perennial Spanish savouries (Satureja montana L., Satureja innota (Pau) G. López, Satureja cuneifolia Ten. and Satureja intricata Lange), was investigated by GC and GC-MS. A total of 72 compounds accounting between 98.25-99.55% of the total oil were identified. High content of carvacrol (59.72±1.50%) followed by g -terpinene (17.40±1.11%) were found in S.montana essential oils. S. cuneifolia yielded an oil rich in camphor (45.04±1.67%) and camphene (12.42±1.71%) whereas S. innota produces an essential oil with linalool (23.94±7.58%) or geraniol (8.62±3.45%) according to th…
Chemical composition and antibacterial activity of essential oil of Pulicaria odora L.
The chemical composition of the volatile oil constituent from Pulicaria odora L. roots has been analyzed by GC/MS. Twenty-seven components were identified, being thymol (47.83%) and its derivative isobutyrate (30.05%) the main constituents in the oil. Furthermore, the oil was tested against seven bacteria at different concentrations. Results showed that the oil exhibited a significant antibacterial activity.