0000000000223854

AUTHOR

Frauke Steindel

showing 3 related works from this author

Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus

2013

Type 1 cannabinoid receptor (CB1) is expressed in different neuronal populations in the mammalian brain. In particular, CB1 on GABAergic or glutamatergic neurons exerts different functions and display different pharmacological properties in vivo. This suggests the existence of neuron-type specific signalling pathways activated by different subpopulations of CB1. In this study, we analysed CB1 expression, binding and signalling in the hippocampus of conditional mutant mice, bearing CB1 deletion in GABAergic (GABA-CB1-KO mice) or cortical glutamatergic neurons (Glu-CB1-KO mice). Compared to their wild-type littermates, Glu-CB1-KO displayed a small decrease of CB1 mRNA amount, immunoreactivity…

Cannabinoid receptorG proteinmedicine.medical_treatmentHippocampusBiologyHippocampal formationHippocampusBiochemistryMice03 medical and health sciencesCellular and Molecular NeuroscienceGlutamatergic0302 clinical medicineGTP-binding protein regulatorsReceptor Cannabinoid CB1GTP-Binding ProteinsmedicineAnimalsGABAergic Neurons030304 developmental biologyMice Knockout0303 health sciencesCannabinoidsmusculoskeletal neural and ocular physiologyfood and beveragesMice Inbred C57BLnervous systemGABAergiclipids (amino acids peptides and proteins)CannabinoidNeurosciencepsychological phenomena and processes030217 neurology & neurosurgeryProtein BindingSignal TransductionJournal of Neurochemistry
researchProduct

Alterations in the Hippocampal Endocannabinoid System in Diet-Induced Obese Mice

2010

The endocannabinoid (eCB) system plays central roles in the regulation of food intake and energy expenditure. Its alteration in activity contributes to the development and maintenance of obesity. Stimulation of the cannabinoid receptor type 1 (CB1receptor) increases feeding, enhances reward aspects of eating, and promotes lipogenesis, whereas its blockade decreases appetite, sustains weight loss, increases insulin sensitivity, and alleviates dysregulation of lipid metabolism. The hypothesis has been put forward that the eCB system is overactive in obesity. Hippocampal circuits are not directly involved in the neuronal control of food intake and appetite, but they play important roles in hed…

Malemedicine.medical_specialtyPolyunsaturated Alkamidesmedicine.medical_treatmentmedia_common.quotation_subjectArachidonic AcidsBiologyHippocampusArticlegamma-Aminobutyric acidGlyceridesMice03 medical and health sciences0302 clinical medicineReceptor Cannabinoid CB1Internal medicineCannabinoid Receptor ModulatorsCannabinoid receptor type 1medicineAnimalsObesityReceptorgamma-Aminobutyric Acid030304 developmental biologymedia_commonMice KnockoutNeurons0303 health sciencesLong-Term Synaptic DepressionGeneral NeuroscienceAppetiteDietary FatsEndocannabinoid systemMice Inbred C57BLDisease Models AnimalLipoprotein LipaseEndocrinologynervous systemSynapsesSynaptic plasticitylipids (amino acids peptides and proteins)CannabinoidDiet-induced obese030217 neurology & neurosurgeryEndocannabinoidsmedicine.drugThe Journal of Neuroscience
researchProduct

Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.

2015

Adolescence is characterized by drastic behavioral adaptations and comprises a particularly vulnerable period for the emergence of various psychiatric disorders. Growing evidence reveals that the pathophysiology of these disorders might derive from aberrations of normal neurodevelopmental changes in the adolescent brain. Understanding the molecular underpinnings of adolescent behavior is therefore critical for understanding the origin of psychopathology, but the molecular mechanisms that trigger adolescent behavior are unknown. Here, we hypothesize that the cannabinoid type-1 receptor (CB1R) may play a critical role in mediating adolescent behavior because enhanced endocannabinoid (eCB) sig…

MaleCannabinoid receptorAdolescentmedicine.medical_treatmentIn Vitro TechniquesImpulsivityMediatorRisk-TakingCocaineReceptor Cannabinoid CB1Sulfur IsotopesmedicineAnimalsHumansMaze LearningRadionuclide ImagingSocial BehaviorCannabinoid Receptor AntagonistsBehavior AnimalGeneral NeuroscienceNovelty seekingAge FactorsBrainArticlesPhenotypeEndocannabinoid systemCorpus StriatumRats Inbred F344RatsAdolescent BehaviorGuanosine 5'-O-(3-Thiotriphosphate)Models AnimalMutationExploratory BehaviorCannabinoid receptor antagonistCannabinoidmedicine.symptomRats TransgenicPsychologyNeuroscienceEndocannabinoidsThe Journal of neuroscience : the official journal of the Society for Neuroscience
researchProduct