0000000000223877
AUTHOR
Matthias Wielscher
Additional file 2: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Characteristics of the participants based on exposure to maternal smoking during pregnancy in the ALSPAC studies. (DOCX 13 kb)
Additional file 6: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
CpG sites and their association with methylation in the ARIES cord blood data. (DOCX 14 kb)
Additional file 4: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Paternal smoking-adjusted association results of exposure to maternal smoking during pregnancy and offspring peripheral blood DNA methylation for the top CpG sites. (DOCX 14 kb)
Additional file 7: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Effect sizes and their 95% confidence intervals of each available SNP-CpG association across different time points in the ARIES data. (DOCX 108 kb)
Additional file 6: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
CpG sites and their association with methylation in the ARIES cord blood data. (DOCX 14 kb)
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults
Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult s…
Additional file 4: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Paternal smoking-adjusted association results of exposure to maternal smoking during pregnancy and offspring peripheral blood DNA methylation for the top CpG sites. (DOCX 14 kb)
Additional file 5: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Mediation analysis examining the mediated effect of maternal smoking during pregnancy on schizophrenia-related personality traits and inflammatory bowel syndrome in the NFBC 1966 cohort. (DOCX 15 kb)
Additional file 3: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Characteristics of the participants based on exposure to maternal smoking during pregnancy in the IOWBC. (DOCX 12 kb)
Additional file 1: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Characteristics of the participants based on exposure to maternal smoking during pregnancy in the NFBC cohorts. (DOCX 14 kb)
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Background Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. Methods We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring. Results We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolesc…
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Funder: British Lung Foundation (BLF); doi: https://doi.org/10.13039/501100000351