0000000000223880
AUTHOR
Juha Veijola
Additional file 2: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Characteristics of the participants based on exposure to maternal smoking during pregnancy in the ALSPAC studies. (DOCX 13 kb)
Additional file 6: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
CpG sites and their association with methylation in the ARIES cord blood data. (DOCX 14 kb)
Additional file 4: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Paternal smoking-adjusted association results of exposure to maternal smoking during pregnancy and offspring peripheral blood DNA methylation for the top CpG sites. (DOCX 14 kb)
Additional file 7: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Effect sizes and their 95% confidence intervals of each available SNP-CpG association across different time points in the ARIES data. (DOCX 108 kb)
Additional file 6: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
CpG sites and their association with methylation in the ARIES cord blood data. (DOCX 14 kb)
Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort
Abstract Delayed childhood development may precede adult psychoses. We tested this hypothesis in a large, general population birth cohort (n=12 058) followed to age 31 years. The ages at which individuals learned to stand, walk, speak, and became potty-trained (bowel control) and dry (bladder control), were recorded at a 1-year examination. Psychiatric outcome was ascertained through linkage to a national hospital discharge register. Cumulative incidence of DSM-III-R schizophrenia, other psychoses and non-psychotic disorders were stratified according to the timing of milestones and compared within the cohort using internal standardization. 100 cases of DSM-III-R schizophrenia, 55 other psyc…
Additional file 4: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Paternal smoking-adjusted association results of exposure to maternal smoking during pregnancy and offspring peripheral blood DNA methylation for the top CpG sites. (DOCX 14 kb)
Additional file 5: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Mediation analysis examining the mediated effect of maternal smoking during pregnancy on schizophrenia-related personality traits and inflammatory bowel syndrome in the NFBC 1966 cohort. (DOCX 15 kb)
Additional file 3: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Characteristics of the participants based on exposure to maternal smoking during pregnancy in the IOWBC. (DOCX 12 kb)
Additional file 1: of DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Characteristics of the participants based on exposure to maternal smoking during pregnancy in the NFBC cohorts. (DOCX 14 kb)
Verbal learning and memory and their associations with brain morphology and illness course in schizophrenia spectrum psychoses.
The California Verbal Learning Test and structural brain imaging were administered to 57 subjects with schizophrenia spectrum disorders and 94 controls in a general population sample. Cases had lower semantic cluster scores. Poorer verbal memory strategies were associated with longer duration of illness and heavier use of antipsychotic medication. After controlling for duration of illness, sex, and total gray matter, poorer verbal memory was associated with lower gray matter volume in the cingulate cortex, juxtapositional lobule, right superior temporal gyrus, and precuneus. After controlling for use of antipsychotic medication, there was an association between higher serial clustering and …
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Background Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. Methods We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring. Results We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolesc…