0000000000225593
AUTHOR
B. Horvath
Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity
Background A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system. Methods A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicenter prospective study. Multivariate logistic regression, discriminant analysis and receiver operating characteristic curves and examination for correlation (Spearman's rho) and agreement (Cohen's kappa) with existing scores were engaged to recognize the v…
Comparative analysis of Medicago truncatula mutants deficient in NCR peptides essential for symbiotic nitrogen fixation
Medicago truncatula, belonging to the inverted repeat-lacking clade (IRLC) of legumes is able to establish one of the most effective nitrogen-fixing symbiotic interaction with the symbiotic partner Sinorhizobium spp. In the infected cells of the M. truncatula nodules, rhizobial genome undergo morphological and metabolic transformation. This differentiation is irreversible in species belonging to the IRLC legumes and this process is driven by the family of the nodule-specific cysteine rich (NCR) peptides produced by the plant. In the M. truncatula genome, approximately 700 genes encode NCR peptides. The high number of genes can imply that the function of NCR peptides may overlap or partially…