0000000000225750

AUTHOR

Ashraf Hanafy

showing 5 related works from this author

Uterus transplantation in a non-human primate: long-term follow-up after autologous transplantation

2012

BACKGROUND Uterus transplantation (UTx) may provide the first available treatment for women affected by uterine infertility. The present study aimed to further develop a surgical technique for autologous UTx in a non-human primate species and to assess long-term function. METHODS Female baboons (n= 16) underwent autologous transplantation of the uterus with the Fallopian tubes and ovaries, performed with a previously published surgical technique (n= 6, Group 1) or using a modified technique (n= 10; Group 2). The uterine arteries were dissected to the proximal end of the anterior branch (Group 1) or the entire (Group 2) internal iliac artery, and the ovarian veins were dissected to the cross…

medicine.medical_specialtyUterusOvaryBreedingIliac ArteryTransplantation AutologousVeinsUreterPregnancymedicine.arteryUterus transplantationmedicineAnimalsAutologous transplantationFallopian TubesPregnancybusiness.industryOvaryUterusRehabilitationObstetrics and GynecologyArteriesmedicine.diseaseInternal iliac arteryMenstruationSurgeryTreatment Outcomemedicine.anatomical_structureReproductive MedicineFemaleRenal veinbusinessFollow-Up StudiesPapioHuman Reproduction
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Uterus transplantation: animal research and human possibilities

2012

Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation. The animal research on uterus transplantation conducted during the past two decades is summarized, and we describe our views regarding a future research-based human attempt.

Uterine DiseasesInfertilityGynecologymedicine.medical_specialtybusiness.industryGeneral surgeryUterusUterusObstetrics and GynecologyOrgan Transplantationmedicine.diseaseTransplantationmedicine.anatomical_structureReproductive MedicineModels AnimalUterus transplantationAnimalsHumansMedicineFemalebusinessInfertility FemaleFertility and Sterility
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Uterine transplantation: one human case followed by a decade of experimental research in animal models

2011

Uterine transplantation (UTx) aims to treat unconditional uterine factor infertility by replacing a non-functioning or non-existing uterus. After one attempt of UTx in the human 10 years ago, intensive research has been performed. The results of these specific studies on surgical technique, ischaemia-reperfusion injury, immunosuppression and fertility are discussed.

GynecologyInfertilitymedicine.medical_specialtyPregnancybusiness.industrymedicine.medical_treatmentmedia_common.quotation_subjectUterusObstetrics and GynecologyImmunosuppressionFertilityGeneral Medicinemedicine.diseaseExperimental researchSurgeryTransplantationUterine transplantationmedicine.anatomical_structuremedicinebusinessmedia_commonAustralian and New Zealand Journal of Obstetrics and Gynaecology
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First clinical uterus transplantation trial: a six-month report.

2014

Objective To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI). Design Prospective observational study. Setting University hospital. Patient(s) Nine AUFI women and their live uterine donors, the majority being mothers. Intervention(s) Live-donor UTx and low-dose induction immunosuppression. Main Outcome Measure(s) Data from preoperative investigations, surgery and follow-up for 6 months. Result(s) Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of …

InfertilityAdultGraft Rejectionmedicine.medical_specialtymedicine.drug_classUterusABO Blood-Group SystemCohort Studiesmedicine.arteryUterus transplantationMedicineHumansProspective StudiesUterine arterybusiness.industryUterusObstetrics and GynecologyPerioperativeMiddle Agedmedicine.diseaseSurgeryClinical trialTransplantationmedicine.anatomical_structureReproductive MedicineBlood Group IncompatibilityTissue TransplantationCorticosteroidFeasibility StudiesFemalebusinessInfertility FemaleImmunosuppressive AgentsFollow-Up StudiesFertility and sterility
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Preclinical report on allogeneic uterus transplantation in non-human primates

2013

Study question Is it possible to perform allogeneic uterus transplantation (UTx) with a donation from a live donor in a non-human primate species and what immunosuppression is needed to prevent rejection? Summary answer Allogeneic UTx in the baboon is a donor- and recipient-safe surgical procedure; immunosuppression with induction therapy and a triple protocol should be used. What is known already UTx may become a treatment for absolute uterine factor infertility. Autologous UTx models have been developed in non-human primates with reports on long-term survival of the uterine grafts. STUDY DESIGN, SIZEAND DURATION: This experimental study included 18 female baboons as uterus donors and 18 f…

Graft Rejectionmedicine.medical_specialtymedicine.medical_treatmentUterusTacrolimusMaintenance ChemotherapyAdrenal Cortex Hormonesmedicine.arteryUterus transplantationmedicineLiving DonorsAnimalsTransplantation HomologousExternal iliac veinAntilymphocyte SerumImmunosuppression TherapyUterine DiseasesHysterectomybusiness.industryRehabilitationGraft SurvivalUterusObstetrics and GynecologyImmunosuppressionInduction ChemotherapyMycophenolic AcidInternal iliac arteryTacrolimusSurgeryTransplantationDisease Models Animalmedicine.anatomical_structureReproductive MedicineFeasibility StudiesDrug Therapy CombinationFemalebusinessInfertility FemalePapio
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