0000000000231065

AUTHOR

Natascha Drude

showing 3 related works from this author

Polymeric Nanoparticles: Polymeric Nanoparticles with Neglectable Protein Corona (Small 18/2020)

2020

BiomaterialsMaterials scienceChemical engineeringAsymmetrical Flow Field-Flow FractionationDrug deliveryGeneral Materials ScienceProtein CoronaGeneral ChemistryPolymeric nanoparticlesBiotechnologySmall
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Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems.

2020

Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using riboflavin may enhance tumor accumulation and internalization of drug delivery systems. To test this hypothesis, butyl-based 3-arm peptostar polymers were synthesized consisting of a lysine core (10 units per arm) and a sarcosine shell (100 units per arm). The end groups of the arms and the core were successfully modified with riboflavin and the Cy-5.5 fluorescent dye, respectively. While in phosphate buffered saline the functionalized peptostars showed a bimodal behavior and formed supramolecular structures over tim…

SarcosinePolymersmedia_common.quotation_subjectRiboflavinLysineBiomedical EngineeringPharmaceutical ScienceBioengineeringRiboflavinchemistry.chemical_compoundIn vivoRiboflavin-carrier proteinMaterials TestingHumansInternalizationmedia_commonPharmacologyDrug CarriersChemistryLysineOrganic ChemistryMembrane Transport ProteinsBiological TransportSarcosineCarbocyaninesCancer cellDrug deliveryPC-3 CellsBiophysicsBiotechnologyBioconjugate chemistry
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Polymeric Nanoparticles with Neglectable Protein Corona

2020

Small : nano micro 16(18), 1907574 (2020). doi:10.1002/smll.201907574

540 Chemistry and allied sciencesDispersity610 Medizinmicellar structuresNanoparticleProtein Corona02 engineering and technology010402 general chemistry01 natural sciencesPolyethylene GlycolsBiomaterialschemistry.chemical_compoundAdsorption610 Medical sciencesHumansGeneral Materials ScienceParticle SizeGel electrophoresisChemistryasymmetrical flow field-flow fractionationSarcosineGeneral Chemistry021001 nanoscience & nanotechnology0104 chemical sciencesChemical engineering540 Chemiedrug deliveryNanoparticlesParticleProtein CoronaParticle sizePeptides0210 nano-technologyHydrophobic and Hydrophilic InteractionsEthylene glycolBiotechnologySmall
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