0000000000234080

AUTHOR

Manfred Sommer

showing 4 related works from this author

Temporary warm ischaemia, 5/6 nephrectomy and single uranylnitrate administration — comparison of three models intended to cause renal fibrosis in ra…

2001

In patients the progression of pathologic renal processes after the treatment of primary disease is a problem of increasing importance and therapeutic strategies are insufficient till now. The aim of this paper was to search for rat models of interstitial fibrosis as a basis for testing therapeutic strategies to prevent end-stage renal failure. Experiments were done on adult female Wistar rats (Han:Wist) to investigate long-term consequences of temporary warm ischaemia, 5/6 nephrectomy (5/6 NX) and single uranyl nitrate (UN) administration (0.3 or 0.5 mg/ 100 g body wt. intraperitoneally). Observation time was 20 weeks after injury in each group. Creatinine clearance, urinary protein excret…

medicine.medical_specialtyPathologyTime Factorsmedicine.medical_treatmentUrologyRenal functionKidneyToxicologyNephrectomyPathology and Forensic MedicineExcretionFibrosismedicineRenal fibrosisAnimalsRats WistarKidneybusiness.industryKidney metabolismCell BiologyGeneral Medicinemedicine.diseaseFibrosisNephrectomyRatsDisease Models AnimalHydroxyprolineProteinuriamedicine.anatomical_structureCreatinineReperfusion InjuryUranyl NitrateNephritis InterstitialFemalebusinessKidney diseaseExperimental and Toxicologic Pathology
researchProduct

Expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction

2000

Unilateral ureteral obstruction (UUO) has been used as an experimental model to induce tubulointerstitial damage and interstitial fibrosis. UUO is characterized by cellular proliferation, accumulation of inflammatory cells, and subsequent replacement of renal parenchyma by fibrous tissue. The influx of inflammatory cells into the renal interstitium is mediated by adhesion molecules. In this study, the development of fibrosis in the UUO model of the rat was examined and its relation to the time course of LFA-1 and ICAM-1 expression was assessed by immunohistochemistry. An increase in interstitial connective tissue was detected on day 10 after UUO, with a maximum on day 35. After unilateral u…

MalePathologymedicine.medical_specialtyConnective tissueCD18Kidneyurologic and male genital diseasesToxicologyPathology and Forensic MedicineRats Sprague-DawleyFibrosisAnimalsMedicineLigationHydronephrosisKidneyurogenital systembusiness.industryCell BiologyGeneral MedicineIntercellular Adhesion Molecule-1medicine.diseaseFibrosisLymphocyte Function-Associated Antigen-1female genital diseases and pregnancy complicationsRatsDisease Models Animalmedicine.anatomical_structureCD18 AntigensNephritis InterstitialImmunohistochemistryUreterbusinessNephritisUreteral ObstructionKidney diseaseExperimental and Toxicologic Pathology
researchProduct

DIN-Norm für PASCAL

1983

Die DIN-Norm Pascal ist aus einer Ubersetzung der ISO 7185 Pascal-Norm entstanden, die zum 1. Dezember 1983 von ISO nach einer mehrjahrigen Entwurfsphase verabschiedet wurde.

Discrete mathematicsNorm (mathematics)Pascal (programming language)computerMathematicscomputer.programming_language
researchProduct

Einführung in die Programmiersprache PASCAL

1983

Das folgende Bild zeigt ein syntaktisch richtiges Pascal-Programm. Es besteht aus dem Programmkopf ① dem Vereinbarungsteil ② dem Anweisungsteil ③ einem abschliesenden Punkt. ④

researchProduct