showing 3 related works from this author
Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome
2020
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by extensive local invasion and systemic spread. In this study, we employed a three-dimensional organoid model of human pancreatic cancer to characterize the molecular alterations critical for invasion. Time-lapse microscopy was used to observe invasion in organoids from 25 surgically resected human PDAC samples in collagen I. Subsequent lentiviral modification and small-molecule inhibitors were used to investigate the molecular programs underlying invasion in PDAC organoids. When cultured in collagen I, PDAC organoids exhibited two distinct, morphologically defined invasive phenotypes, mesenchymal an…
A Design of Global Workspace Model with Attention: Simulations of Attentional Blink and Lag-1 Sparing
2022
There are many developed theories and implemented artificial systems in the area of machine consciousness, while none has achieved that. For a possible approach, we are interested in implementing a system by integrating different theories. Along this way, this paper proposes a model based on the global workspace theory and attention mechanism, and providing a fundamental framework for our future work. To examine this model, two experiments are conducted. The first one demonstrates the agent’s ability to shift attention over multiple stimuli, which accounts for the dynamics of conscious content. Another experiment of simulations of attentional blink and lag-1 sparing, which are two well-stu…
A Cognitive Robotics Implementation of Global Workspace Theory for Episodic Memory Interaction with Consciousness
2023
Abstract—Artificial general intelligence revived in recent years after people achieved significant advances in machine learning and deep learning. This leads to the thinking of how real intelligence could be created. Consciousness theories believe that general intelligence is essentially conscious, yet no universal definition is agreed upon. In this work, Global Workspace Theory is implemented and integrated with crucial cognitive components. With the focus on episodic memory and inspiration from the nature of episodic memory in psychology and neuroscience, the episodic memory component is implemented within the Global Workspace framework. In our experiment, the robotic agent operates in a …