0000000000234801
AUTHOR
Kohei Fujikura
showing 2 related works from this author
Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome
2020
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by extensive local invasion and systemic spread. In this study, we employed a three-dimensional organoid model of human pancreatic cancer to characterize the molecular alterations critical for invasion. Time-lapse microscopy was used to observe invasion in organoids from 25 surgically resected human PDAC samples in collagen I. Subsequent lentiviral modification and small-molecule inhibitors were used to investigate the molecular programs underlying invasion in PDAC organoids. When cultured in collagen I, PDAC organoids exhibited two distinct, morphologically defined invasive phenotypes, mesenchymal an…
Microlensing constraints on axion stars including finite lens and source size effects
2021
A fraction of light scalar dark matter, especially axions, may organize into Bose-Einstein condensates, gravitationally bound clumps, "boson stars", and be present in large number in galactic halos today. We compute the expected number of gravitational microlensing events of clumps composed of the ordinary QCD axion and axion-like-particles and derive microlensing constraints from the EROS-2 survey and the Subaru Hyper Suprime-Cam observation. We perform a detailed lensing calculation, including the finite lens and source size effects in our analysis. We constrain the axion mass in terms of the fraction of dark matter collapsed into clumps, the individual clump densities, and the axion self…