0000000000236521

AUTHOR

Jianming Zhang

showing 4 related works from this author

Online Multi-Person Tracking by Tracker Hierarchy

2012

Tracking-by-detection is a widely used paradigm for multi-person tracking but is affected by variations in crowd density, obstacles in the scene, varying illumination, human pose variation, scale changes, etc. We propose an improved tracking-by-detection framework for multi-person tracking where the appearance model is formulated as a template ensemble updated online given detections provided by a pedestrian detector. We employ a hierarchy of trackers to select the most effective tracking strategy and an algorithm to adapt the conditions for trackers' initialization and termination. Our formulation is online and does not require calibration information. In experiments with four pedestrian t…

Computer scienceBitTorrent trackerbusiness.industryComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONInitializationTracking systemTracking (particle physics)Object detectionActive appearance modelVideo trackingTracking Experts DetectorComputer visionArtificial intelligenceMean-shiftbusiness
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Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.

2014

Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification of effective pharmacological strategies to target SCLC biology represents an urgent need. Using a high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to transcription-targeting drugs, in particular to THZ1, a recently identified covalent inhibitor of cyclin-dependent kinase 7. We find that expression of super-enhancer-associated transcription factor genes, including MYC family proto-oncogenes and neuroendocrine lineage-specific factors, is highly vulnerability to THZ1 treatment. We propose that downregulation of these transcription factors contribut…

Cancer ResearchLung NeoplasmsTranscription GeneticMolecular Sequence DataAntineoplastic AgentsBiologyBioinformaticsArticleMiceSuper-enhancerDownregulation and upregulationCell Line TumorMedicineAnimalsHumansEnzyme InhibitorsneoplasmsTranscription factorRegulation of gene expressionbusiness.industryCell BiologyNeoplasms ExperimentalSequence Analysis DNASmall Cell Lung CarcinomaXenograft Model Antitumor AssayshumanitiesCyclin-Dependent Kinasesrespiratory tract diseasesHigh-Throughput Screening AssaysGene Expression Regulation NeoplasticOncologyCovalent bondCancer cellCancer researchNon small cellSmall Cell Lung CarcinomaCyclin-dependent kinase 7businessTranscription Factor GeneCDK12Transcription FactorsCancer cell
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Decoding Children's Social Behavior

2013

We introduce a new problem domain for activity recognition: the analysis of children's social and communicative behaviors based on video and audio data. We specifically target interactions between children aged 1-2 years and an adult. Such interactions arise naturally in the diagnosis and treatment of developmental disorders such as autism. We introduce a new publicly-available dataset containing over 160 sessions of a 3-5 minute child-adult interaction. In each session, the adult examiner followed a semi-structured play interaction protocol which was designed to elicit a broad range of social behaviors. We identify the key technical challenges in analyzing these behaviors, and describe met…

Behavior Psychology Dataset Video analysis Speech Analysis AutismInter-action protocolsSocial and communicative behaviorInteraction protocol02 engineering and technologycomputer.software_genreAnnan data- och informationsvetenskapSession (web analytics)Activity recognitionTechnical challenges0202 electrical engineering electronic engineering information engineeringmedicineSocial behaviorAudio signal processingMultimediabusiness.industryDevelopmental disorders020207 software engineeringmedicine.diseaseSemi-structuredResearch questionsActivity recognitionProblem domainKey (cryptography)Autism020201 artificial intelligence & image processingArtificial intelligencePsychologybusinessOther Computer and Information SciencecomputerCognitive psychologySocial behavior2013 IEEE Conference on Computer Vision and Pattern Recognition
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Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer

2013

Abstract The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non–small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrative approach to define novel therapeutic targets in KRAS-driven LKB1-mutant lung cancers. High-throughput RNA interference screens in lung cancer cell lines from genetically engineered mouse models driven by activated KRAS with or without coincident Lkb1 deletion led to the identification of Dtymk, encoding deoxythymidylate kinase (DTYMK), which catalyzes dTTP biosynthesis, as synthetica…

DNA Replicationcongenital hereditary and neonatal diseases and abnormalitiesLung NeoplasmsMutantSTK11BiologyAMP-Activated Protein KinasesProtein Serine-Threonine Kinasesmedicine.disease_causeArticleProto-Oncogene Proteins p21(ras)MiceDeoxythymidylate kinaseAMP-Activated Protein Kinase KinasesRNA interferenceCell Line TumorCarcinoma Non-Small-Cell LungmedicineMetabolomicsThymine NucleotidesAnimalsHumansMolecular Targeted TherapyLung cancerskin and connective tissue diseasesCell DeathModels GeneticKinaseCell growthGenomicsmedicine.diseaseMolecular biologyHigh-Throughput Screening AssaysOncologyGene Knockdown TechniquesCancer researchRNA InterferenceKRASNucleoside-Phosphate KinaseDNA Damage
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