0000000000237077

AUTHOR

K. H. Holtermüller

showing 3 related works from this author

D-penicillamine in Wilson's disease presenting as acute liver failure with hemolysis.

1982

Wilson's disease in a young woman presenting with an acute course is described. The clinical manifestations were fulminant hepatic failure associated with marked intravascular hemolysis. Immediate D-penicillamine and high-dose steroid therapy did not influence the course of the disease. Necropsy revealed an increased hepatic copper content and cirrhosis with extensive necrosis of the liver.

medicine.medical_specialtyPathologyCirrhosisAdolescentPhysiologyDiseaseGastroenterologyHemolysisFulminant hepatic failureHepatolenticular DegenerationInternal medicinemedicineHumansGlucocorticoidsbusiness.industryLiver DiseasesPenicillaminePenicillamineGastroenterologyLiver failureCeruloplasminHepatologyMiddle Agedmedicine.diseaseHemolysisWilson's diseaseAcute DiseaseFemalebusinessCoppermedicine.drugDigestive diseases and sciences
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Gallstone dissolution with chenodeoxycholic acid. A clinical study.

1980

Out of 95 patients with radiolucent gallstones who enrolled in a clinical study with chenodeoxycholic acid (CDC) for gallstone dissolution 75 patients with cholecystolithiasis completed 12 months of treatment. As a side effect 31% of patients reported intermittent diarrhea which did not cause cessation of therapy or missing of work. The incidence of biliary colic was markedly decreased during treatment in comparison to the rate in the year before. From more than 20 laboratory values checked before start and every 3 months during therapy only aminotransferases increased up to 3 fold in 20% of patients. gamma-GT elevated in 31% of patients before treatment improved in half of these patients d…

AdultDiarrheaMalemedicine.medical_specialtyAdolescentBiliary colicBody weightChenodeoxycholic AcidGastroenterologyClinical studyGallstone dissolutionchemistry.chemical_compoundCholelithiasisChenodeoxycholic acidInternal medicineDrug DiscoverymedicineHumansIn patientGenetics (clinical)AgedDiminutionDose-Response Relationship Drugbusiness.industryBody WeightGeneral MedicineGallstonesMiddle Agedmedicine.diseasechemistrySolubilityMolecular MedicineFemalemedicine.symptombusinessConstipationKlinische Wochenschrift
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The influence of oral contraceptives on the composition of bile.

1982

The increased risk of cholelithiasis during intake of oral contraceptives may be due to estrogen-induced saturation of the bile with cholesterol. In a randomized, prospective, crossed-over double-blind study 20 healthy women after roentgenological exclusion of gall-stones received either 1.0 mg of norethindrone acetate and 50 microgram ethinyl estradiol daily - as usual in oral contraception - for 21 days with 7 days of placebo treatment in each cycle or one fifth of this hormone dose in form of a continuous daily medication. After a 4 month's treatment the medication form was crossed-over. At the beginning of the study, before the cross-over and after the study bile was collected by duoden…

Adultmedicine.medical_specialtyNauseamedia_common.quotation_subjectGallbladder diseasePhysiologyEthinyl EstradiolContraceptives Oral HormonalMenstruationchemistry.chemical_compoundCholelithiasisInternal medicineDrug DiscoverymedicineBileHumansProspective cohort studyGenetics (clinical)Menstrual cyclemedia_commonbusiness.industryCholesterolGeneral Medicinemedicine.diseaseEndocrinologyCholesterolchemistryHormonal contraceptionVomitingMolecular MedicineFemalemedicine.symptomNorethindronebusinessContraceptives OralKlinische Wochenschrift
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