0000000000237101
AUTHOR
Edoardo D'angelo
Correction to: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases
No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC).A series of 22 ENE-positive CRCs was considered and three samples per case were selected (the primary CRC, an ENE-negative and an ENE-positive metastatic LN). Samples (n = 66) were analysed by immunohistochemistry for PD-L1, CD4, CD8, CD68 and CD80. Fifteen out of twenty-two cases were further profiled through a hotspot multigene mutational custom panel, including 164 hotspot regions ofA significantly higher percentage of CD4-, CD8- and CD68-positive cells was observed at the invasive front of both CRCs and in ENE in contrast with what observed at the …
ALIM (Archivio della Latinità Medievale dItalia). Storia, attualità, prospettive di una banca-dati di testi mediolatini
Nella prima parte dell'articolo (paragrafi 1-3), Edoardo D'Angelo ha scritto sulla storia e gli obiettivi di ALIM. La seconda parte dell'articolo (paragrafi 4-10), scritta da Paolo Monella, discute gli aspetti informatico-umanistici della transizione del progetto ALIM da una codifica procedurale (HTML) e proprietaria dei testi e dei loro metadati a standard descrittivi (TEI XML) e open source, e propone in chiusura una riflessione sui modelli di collaborazione tra umanisti, umanisti informatici e informatici all'interno del progetto. In the first part of this article (paragraphs 1-3), Edoardo D'Angelo wrote about the history and goals of ALIM. In the second part (paragraphs 4-10), Paolo Mon…
Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases
Background: No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC). Methods: A series of 22 ENE-positive CRCs was considered and three samples per case were selected (the primary CRC, an ENE-negative and an ENE-positive metastatic LN). Samples (n=66) were analysed by immunohistochemistry for PD-L1, CD4, CD8, CD68 and CD80. Fifteen out of twenty-two cases were further profiled through a hotspot multigene mutational custom panel, including 164 hotspot regions of AKT1, APC, BRAF, CTNNB1, KIT, KRAS, NRAS, PDGFRA, PIK3CA, PTEN and TP53 genes. Results: A significantly higher percentage of CD4-, CD8- and CD68-pos…