Carotid plaque detection improves the predictve value of CHA2DS2-VASc score in patients with non-valvular atrial fibrilation: The ARAPACIS Study

Abstract Background and aims Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHA 2 DS 2 -VASc score. We investigated if systemic atherosclerosis as detected by ultrasound carotid plaque (CP) could improve the predictive value of the CHA 2 DS 2 -VASc score. Methods We analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography. Results VD was reported in 351 (17.3%) patients while CP was detected in 16.6% patients. Ad…

Out of Pile Thermo-Mechanical Testing of Breeder Pebble Beds for HCPB TBM for ITER

Final report on the test campaigns HELICA I-II performed in HEFUS facility

Preparation of HEXCALIBER tests and preliminary thermo-mechanical analyses

Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, pati…

Progress in the benchmark exercise for analyzing the lithiate breeder pebble bed thermo-mechanical behaviour

The Helium Cooled Pebble Bed (HCPB) Blanket is one of the reference concepts for the European Breeding Blanket Programme for DEMO. In the reference blanket module, alternate layers of lithiated ceramics and beryllium pebbles act, respectively, as tritium breeder and neutron multiplier. The thermo-mechanical behaviour of both the pebble beds and their performances in reactor relevant conditions are also dependent on the pebble size and cell geometries (bed thickness, pebble packing factor, bed thermal conductivity). Therefore, in the EU Fusion Technology Programme, several out-of-pile experimental test campaigns have been performed to determine these behaviours. Theoretical calculations have…

Experimental tests on Li-ceramic breeders for the helium cooled pebble bed (HCPB) blanket design

The Helium Cooled Pebble Bed (HCPB) Test Blanket Module (TBM) to be tested in ITER (International Thermonuclear Experimental Reactor) Reactor foresees the utilization of Lithiate ceramics as Tritium breeder in form of pebble beds. Since 1998, ENEA has launched many experimental activities for the evaluation of the breeder thermomechanics and the interaction between the pebble beds and the prismatic steel containment walls. Main objectives of these activities are the measurement of the pebble bed effective thermal conductivity, the wall heat transfer coefficient, the pressure loads and deformations on the lateral walls and their dependency from the mechanical constraints. The paper presents …