0000000000239312

AUTHOR

Patrick Netter

showing 3 related works from this author

HIGH-FIELD MAGNETIC-RESONANCE-IMAGING (MRI) OF THE RABBIT KNEE

1992

International audience

[ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging[INFO.INFO-IM] Computer Science [cs]/Medical Imaging[INFO.INFO-IM]Computer Science [cs]/Medical ImagingComputingMilieux_MISCELLANEOUS
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Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs

1997

International audience; The discovery of at least 2 cyclo-oxygenase (COX) isoenzymes, referred to as COX-1 and COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This has lead investigators to reconsider what can be awaited from this class of drugs. The 2 COX isoenzymes share structural and enzymatic similarities, but are specifically regulated at the molecular level and may be distinguished apart in their functions, although some physiological overlap between them does occur. The major goal in developing selective COX inhibitors is to improve NSAID tolerability. Classic NSAIDs preferentially inhibit COX-1 in vitro, but it appears hazardous to judge their gas…

[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionMESH: Prostaglandin-Endoperoxide SynthasesAnti-Inflammatory AgentsPharmacologyNabumetoneMESH: Cyclooxygenase InhibitorsPharmacotherapymedicineMESH : Anti-Inflammatory Agents Non-SteroidalAnimalsHumansPharmacology (medical)Cyclooxygenase InhibitorsMESH: AnimalsAdverse effectMESH: HumansMESH : Prostaglandin-Endoperoxide Synthasesbusiness.industryMESH : HumansAnti-Inflammatory Agents Non-SteroidalMESH : Cyclooxygenase InhibitorsMESH: Anti-Inflammatory Agents Non-SteroidalClinical trial[SDV.AEN] Life Sciences [q-bio]/Food and NutritionMeloxicamTolerabilityProstaglandin-Endoperoxide SynthasesMESH : AnimalsCyclo-oxygenaseNon-Steroidalbusiness[SDV.AEN]Life Sciences [q-bio]/Food and NutritionNimesulidemedicine.drug
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Redox state alteration modulates astrocyte glucuronidation.

2004

We have investigated the effects of mild oxidative conditions on drug-metabolizing enzyme activity in rat cultured astrocytes. These experimental conditions promoting an oxidative environment were obtained by short exposure to a low concentration of menadione (5 microM) for a short duration (15 min). This resulted in the rapid and transient production of reactive oxygen species (+130%), associated with a decrease in GSH cellular content (-24%), and an increase in total protein oxidation (+26%), but promoted neither PGE(2) nor NO production. This treatment induced a rapid and persistent decrease in astrocyte glucuronidation activities, which was totally prevented by N-acetyl-l-cysteine. Thes…

MaleCell SurvivalGlucuronidationApoptosisGlucuronatesOxidative phosphorylationmedicine.disease_causeProtein oxidationBiochemistryRedoxchemistry.chemical_compoundMenadionePhysiology (medical)CricetinaemedicineAnimalsProtein IsoformsRNA MessengerGlucuronosyltransferaseRats WistarPromoter Regions GeneticCells Culturedchemistry.chemical_classificationInflammationReactive oxygen speciesBase SequenceVitamin K 3GlutathioneHydrogen PeroxideMolecular biologyGlutathioneCell biologyRatschemistryAstrocytesFemaleReactive Oxygen SpeciesOxidation-ReductionOxidative stressFree radical biologymedicine
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