0000000000240161
AUTHOR
Katrin Amunts
Nervensystem und Sinnesorgane
Das Nervensystem wird in ein zentrales und ein peripheres Nervensystem gegliedert. Unter dem Begriff zentrales Nervensystem (ZNS) werden Ruckenmark und Gehirn zusammengefasst. Das periphere Nervensystem (PNS) beinhaltet die Nerven und Ganglien auserhalb des ZNS. Davon abgegrenzt wird noch ein enterisches Nervensystem, das Nervensystem der Eingeweide.
Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice – A quantitative multireceptor study
Parkinson's disease (PD) is a well-characterized neurological disorder with regard to its neuropathological and symptomatic appearance. At the genetic level, mutations of particular genes, e.g. Parkin and DJ-1, were found in human hereditary PD with early onset. Neurotransmitter receptors constitute decisive elements in neural signal transduction. Furthermore, since they are often altered in neurological and psychiatric diseases, receptors have been successful targets for pharmacological agents. However, the consequences of PD-associated gene mutations on the expression of transmitter receptors are largely unknown. Therefore, we studied the expression of 16 different receptor binding sites …
Neurotransmitter receptor density changes in Pitx3ak mice – A model relevant to Parkinson’s disease
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by alterations of nigrostriatal dopaminergic neurotransmission. Compared to the wealth of data on the impairment of the dopamine system, relatively limited evidence is available concerning the role of major non-dopaminergic neurotransmitter systems in PD. Therefore, we comprehensively investigated the density and distribution of neurotransmitter receptors for glutamate, GABA, acetylcholine, adrenaline, serotonin, dopamine and adenosine in brains of homozygous aphakia mice being characterized by mutations affecting the Pitx3 gene. This genetic model exhibits crucial hallmarks of PD on the ne…