0000000000240334
AUTHOR
Alexandra Rousseau
Hospital Admissions for Acute Myocardial Infarction Before and After Lockdown According to Regional Prevalence of COVID-19 and Patient Profile
Aim: to evaluate the impact of a nationwide lockdown in France on acute myocardial infarction (AMI) admissions, by patient characteristics and regional prevalence of the pandemic. Methods and Results: We collected data from 21 centres participating in the on-going FRENCHIE registry (NCT04050956), which collects data from all patients admitted for STEMI or NSTEMI within 48 hours of symptom onset. We compared weekly admissions in the 4 weeks preceding and the 4 weeks following institution of the lockdown. We observed a brutal 30% decrease in AMI admissions (24% for STEMI and 36% for NSTEMI, P=0.14) following institution of the lockdown, with similar trends according to gender (30% decrease in…
Additional file 6 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 6. (A) Sorensen similarity index between donor and recipient fecal microbiota 6 weeks after FMT or sham, separating “FMT” failure from “FMT success”.
Additional file 10 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 10. Clinical efficacy of FMT is associated with colonization by the donor microbiota. Flare-free survival of patients in the FMT and the Sham groups.
Additional file 9 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 9. Evolution of similarity index (1-unweighted Unifrac) between donor and recipient fecal microbiota in patients with FMT success and FMT failure.
Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Abstract Background The role of the gut microbiota in Crohn’s disease (CD) is established and fecal microbiota transplantation (FMT) is an attractive therapeutic strategy. No randomized controlled clinical trial results are available. We performed a randomized, single-blind, sham-controlled pilot trial of FMT in adults with colonic or ileo-colonic CD. Method Patients enrolled while in flare received oral corticosteroid. Once in clinical remission, patients were randomized to receive either FMT or sham transplantation during a colonoscopy. Corticosteroids were tapered and a second colonoscopy was performed at week 6. The primary endpoint was the implantation of the donor microbiota at week 6…
Additional file 2 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 2. Screening measures for donors.
Additional file 5 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 5. Change in clinical and biological parameters between day 0 and week 6 for FMT and sham treatment groups.
Hospital admissions for acute myocardial infarction before and after lockdown according to regional prevalence of COVID-19 and patient profile in France: a registry study
Background The COVID-19 pandemic has had a profound effect on general health care. We aimed to evaluate the effect of a nationwide lockdown in France on admissions to hospital for acute myocardial infarction, by patient characteristics and regional prevalence of the pandemic. Methods In this registry study, we collected data from 21 centres participating in the ongoing French Cohort of Myocardial Infarction Evaluation (FRENCHIE) registry, which collects data from all patients admitted for ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI) within 48 h of symptom onset. We analysed weekly hospital admissions over 8 weeks: the 4 weeks …
Additional file 4 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 4. Characteristics of patients at selection (before starting corticosteroids.
Additional file 1 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 1: Study design.
Additional file 8 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 8. Abundance of taxa at the genus/species level during the follow-up period in patients with FMT success (A) and FMT failure (B). Proportion of different OTU from donors in patients with FMT success and FMT failure (C). Only taxa representing > 0.1% of the microbiota were taken into account in the analysis.
Additional file 7 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 7. Principal coordinate analysis of Bray–Curtis distance in patients with FMT failure (A) or FMT sucess (B). Each PCoA plot represent the samples from a single patient across the different time points. PC1, PC2 and PC3 represent the top three principal coordinates that captured most of the diversity. The fraction of diversity captured by the coordinate is given as a percentage.
Additional file 3 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
Additional file 3. Raw sequence data.