0000000000240422
AUTHOR
Andrea Grilli
Abstract A42: miR34a: A valuable indicator of differential outcome of Ewing sarcoma patients with complex functions
Abstract The identification of reliable indicators of prognosis, which may allow the stratification of patients according to different risk at diagnosis isan important aspect of translational research in Ewing sarcoma (ES). In this paper, we validated our previous evidence showing how expression of miR34a in ES tumor samples at diagnosis was signficantly associated with tumor progression (Nakatani F. J Pathol 2012). Here we analyzed a different series of speciments derived from very controlled and homogeneously treated non-metastatic ES patients, and we compared evaluation of miR34a by RT-PCR using frozen samples with that obtained by in situ hybridization on paraffin-embedded samples . The…
Experimental Investigation on Water Loss and Stiffness of CBTM Using Different RA Sources
Cold recycling of reclaimed asphalt (RA) is a promising technique to build or to maintain roads, combining performance and environmental advantages. Although this technique has been extensively used worldwide, there is no unique and internationally-shared method to characterize cold recycled mixtures. The previous work of the RILEM TC 237-SIB TG6 successfully attempted to characterize different RA sources with both traditional parameters (gradation, bitumen content and geometrical properties) and non-conventional properties (fragmentation and strength testing). The current RILEM TC 264-RAP TG1 mainly focuses on the influence of different RA sources on physical and mechanical characteristics…
Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression.
ABSTRACT Background At diagnosis, identification of reliable biological indicators of prognosis to allow stratification of patients according to different risks is an important but still unresolved aspect in the treatment of Ewing sarcoma (EWS) patients. This study aimed to explore the role of miR-34A expression on prognosis of EWS patients. Patients and methods Specimens from 109 patients with non-metastatic EWS treated at the Rizzoli Institute with neoadjuvant chemotherapy (protocols ISG/SSGIII, EW-1, EW-2, EW-REN2, EW-REN3, EW-PILOT) and 17 metastases were studied. Sixty-eight patients (62%) remained disease-free and 41 (38%) relapsed (median follow-up: 67 months, range 9–241 months). Ex…
Recommendation of RILEM TC237-SIB on fragmentation test for recycled asphalt
This recommendation describes how to characterize the reclaimed asphalt through the fragmentation test. The guidelines given hereafter are based on the results of a round robin test organized by the RILEM Technical Committee 237-SIB ‘‘Testing and characterization of sustainable innovative bituminous materials and systems’’ and provide information on the testing procedure, data analysis and indications for the preparation of a test report.
Recommendation of RILEM TC237-SIB: protocol for characterization of recycled asphalt (RA) materials for pavement applications
This recommendation proposes an experimental protocol to characterize Recycled Asphalt (RA) materials. The guidelines presented in this document are based on the results of a Round Robin Test (RRT) organized by the RILEM Technical Committee 237-SIB “Testing and characterization of sustainable innovative bituminous materials and systems” and provide information on the testing procedure, data analysis and indications for the preparation of a test report.
Recommendation of RILEM TC237-SIB on cohesion test of recycled asphalt
This recommendation describes how to evaluate the presence of potentially active bitumen in recycled asphalt (RA) materials through the cohesion test. The experimental protocol is designed according to the research performed by the RILEM Technical Committee 237-SIB ‘‘Testing and characterization of sustainable innovative bituminous materials and systems’’ with the purpose, to develop a new, simple and fast method for the characterization of RA while limiting the need for conventional rheological tests. The guidelines in this recommendation focus on the testing procedure including specimen preparation, data analysis and provide information on the preparation of a tests report.
Cold recycling of reclaimed asphalt pavements
Pavement engineers have in front of them multiple challenges linked to addressing issues related to social development and society’s expanding needs. One of the most substantial of these issues is perhaps how to effectively rehabilitate and/ or maintain the existing road network while preserving and sustaining limited natural resources. The re-usage of existing pavement materials to reconstruct/ rehabilitate our future pavements is the solution that is now more and more selected by the different road administrations around the world. However, upon closer inspection, one can find many areas and details, not negligible issues, that are simply extensions of HMA technology (i.e. mix design proc…