0000000000240532
AUTHOR
L. Gallego
Integridad renal y hepática tras la sedación prolongada con sevoflurano administrado a través del dispositivo AnaConDa®: comparación con la sedación intravenosa con propofol en modelo animal
Resumen Introduccion En la actualidad la sedacion de los pacientes criticos se realiza mediante agentes intravenosos. La utilizacion de agentes inhalatorios, como alternativa a la sedacion intravenosa, se encuentra limitada por su potencial riesgo de toxicidad. El incremento de los niveles de fluoruros inorganicos, tras su metabolizacion, ha sido considerado potencialmente nefrotoxico. Por otro lado, la afectacion hepatica despues de la administracion prolongada de sevoflurano no ha sido estudiada. Se evaluo la potencial toxicidad renal y hepatica causada por la administracion prolongada (72 h) de sevoflurano. Metodos Estudio experimental, prospectivo, aleatorizado y controlado. Veintidos a…
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Renal and hepatic integrity in long-term sevoflurane sedation using the anesthetic conserving device: A comparison with intravenous propofol sedation in an animal model
Abstract Introduction Critically ill patients are sedated with intravenous agents because the use of inhaled agents is limited by their potential risk of toxicity. Increasing levels of inorganic fluorides after the metabolism of these agents have been considered potentially nephrotoxic. However, hepatic involvement after prolonged administration of sevoflurane has not yet been studied. The present study evaluated the potential renal and hepatic toxicity caused by prolonged administration (72 h) of sevoflurane. Methods For this experimental, prospective, randomized, controlled trial, 22 Landrace × Large-White female pigs were randomly assigned to two groups: intravenous propofol (P) or inhal…