0000000000240928
AUTHOR
Henrihs Gorskis
Lack of significant differences between gastrointestinal tract microbial population structure of Helicobacter pylori-infected subjects before and 2 years after a single eradication event.
Background According to recent estimates 80% of Latvian population is infected with Helicobacter pylori thus their susceptibility to numerous gastric tract diseases is increased. The 1st line H. pylori eradication therapy includes treatment with clarithromycin in combination with amoxicillin or metronidazole and a proton pump inhibitor. However, potential adverse events caused by such therapies to microbiome are insufficiently studied. Objective This study aimed to evaluate the long-term effect of H. pylori eradication on human gastrointestinal tract (GIT) microbiome. Methods The assessment of H pylori eradication impact on GIT microbiome was done by analyzing 120 samples acquired from 60 s…
Entropy-Based Classifier Enhancement to Handle Imbalanced Class Problem
The paper presents a possible enhancement of entropy-based classifiers to handle problems, caused by the class imbalance in the original dataset. The proposed method was tested on synthetic data in order to analyse its robustness in the controlled environment with different class proportions. As also the proposed method was tested on the real medical data with imbalanced classes and compared to the original classification algorithm results. The medical field was chosen for testing due to frequent situations with uneven class ratios.