0000000000241106

AUTHOR

Stefano Martinelli

showing 2 related works from this author

Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-i…

2022

Summary Background Vancomycin is the most widely used antibiotic for neonatal Gram-positive sepsis, but clinical outcome data of dosing strategies are scarce. The NeoVanc programme comprised extensive preclinical studies to inform a randomised controlled trial to assess optimised vancomycin dosing. We compared the efficacy of an optimised regimen to a standard regimen in infants with late onset sepsis that was known or suspected to be caused by Gram-positive microorganisms. Methods NeoVanc was an open-label, multicentre, phase 2b, parallel-group, randomised, non-inferiority trial comparing the efficacy and toxicity of an optimised regimen of vancomycin to a standard regimen in infants aged …

medicine.medical_specialtyTime FactorsPopulationEquivalence Trials as TopicLoading doseArticlelaw.inventionGram-positiveRandomized controlled triallawVancomycinIntensive careInternal medicineIntensive Care Units NeonatalSepsisDevelopmental and Educational PsychologyClinical endpointMedicineHumansDosingeducationInfusions Intravenouseducation.field_of_studybusiness.industryInfant NewbornInfantdosingUnited KingdomAnti-Bacterial AgentsEuropeRegimenTreatment OutcomeSpainRelative riskPediatrics Perinatology and Child Healthsepsibusiness
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Association of maternal hypertension and chorioamnionitis with preterm outcomes

2014

OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS: Overall mortality was higher after hypertension than after chorioamnionitis (odds rati…

MalePediatricsLogistic models; Mortality; Outcomes; Pregnancy complications; Preterm infants; Risks; Female; Gestational Age; Humans; Infant Newborn; Infant Premature Diseases; Male; Pregnancy; Pregnancy Outcome; Prospective Studies; Chorioamnionitis; Hypertension Pregnancy-Induced; Pediatrics Perinatology and Child Health; Medicine (all); Arts and Humanities (miscellaneous)DiseasesInfant Premature DiseasesChorioamnionitisoutcomesPediatricsPregnancyRisksMaternal hypertensionProspective StudiesriskObstetricspregnancy complicationsMedicine (all)Pregnancy OutcomeGestational ageRetinopathy of prematurityPerinatology and Child HealthChorioamnionitisSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICALogistic models Mortality Outcomes Pregnancy complications Preterm infants RisksNecrotizing enterocolitisHypertensionoutcomeFemaleHumanmedicine.medical_specialtyGestational AgeOutcomesPregnancy-Inducedpreterm infantPregnancy complicationArts and Humanities (miscellaneous)medicineLogistic models; Mortality; Outcomes; Pregnancy complications; Preterm infants; Risks; Female; Gestational Age; Humans; Infant Newborn; Infant Premature Diseases; Male; Pregnancy; Pregnancy Outcome; Prospective Studies; Chorioamnionitis; Hypertension Pregnancy-Induced; Pediatrics Perinatology and Child HealthHumanspreterm infantsMortalityPrematurelogistic modelPregnancyChorioamnionitibusiness.industryInfant NewbornPreterm infantsInfantInfant Premature DiseaseOdds ratioHypertension Pregnancy-Inducedmedicine.diseaseNewbornmortalityLogistic modelsProspective StudiePregnancy complicationsBronchopulmonary dysplasiaPediatrics Perinatology and Child Healthbusinesslogistic modelsrisks
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