6533b852fe1ef96bd12ab934
RESEARCH PRODUCT
Association of maternal hypertension and chorioamnionitis with preterm outcomes
Gagliardi LuigiRusconi FrancaRoberto BellùRinaldo ZaniniGianpaolo MirriManuela CondòDaniela TuroliMara VanzatiFabio MoscaGiuseppe De NisiPaola PolaccoElena VillaMario BarbariniValeria FasolatoCaterina FrancoRaffaella ContieroSerena ElleroLuigi CattarossiLaura AbbiatiCesarina BorroniGiovanna PrandiClaudio FabrisFrancesca VielmiSilvia BorgioneMassimo AgostiFrancesco TandoiRosanna GuidaliMario De CurtisClaudio TozziRenato LucchiniMarina BattaglioliGian Luca ListaPaola IntroviniFabrizio FerrariClaudio GalloElvira BellanteChiara BotturaAurelija ZeringyteFrancesca PasqualiSimona BoccacciGiuseppe LatiniRaffaella GiannuzziStefano MartinelliAlberto BrunelliMaria Lucia Di NunzioAntonio VendemmiatiGiovanna CarliMichela Alfiero BordigatoMarco FilipponeDavide MeneghessoNicola RomeoPalma MammolitiEmanuele MastrettaLaura BarberisDaniele FarinaGianpaolo GanciaCristina DalmazzoMarcello NapolitanoFrancesco MessinaNapoli Villa BetaniaRosario MagaldiMatteo RinaldiRosangela LittaPaola LagoVincenzo ZanardoLino ChiandettiStefano VisentinGiuseppe PrestaDavide CellaCarlo PoggianiDaniela FerrariSara ParatiFrancesco LombardoRosetta GrigorioGraziano BareraMaddalena BoveAntonella PoloniatoGiampiero BurgioElena SalaIgnazio BarberiVenera TiralongoAlessandro ArcoDanila MazzeoCarlo DaniSimone PratesiValeria MignattiGina AncoraGiacomo FaldellaSara GrandiChiara LocatelliMauro StronatiGianfranco PerottiGaetano ChiricoClaudio MiglioriSergio De MariniVincenzo ForleoRoberto PaludettoLetizia CapassoGiuseppina MansiFrancesco RaimondiGianni BonaIlaria StucchiSilvia SavastioFederica FerreroAndrea ParolaEzio Maria PadovaniElena VivianiLaura PecoraroRocco AgostinoCamilla GizziLuca MassenziHubert MessnerAlex StafflerGennaro SalviaLuigi EspositoVincenzo ForziatiGiuseppe LatorreFabrizio SandriStefania AlatiFabrizio DemarcaOreste LombardiCarmine Deni CostabileGianfranco ScarpelliClaudio CavalliEnrico VolanteSabrina MorettiOlga GanguzzaBartolomeo SpinellaCristina HaassEleonora ScapillatiChiara ConsigliAlberto GattaPasqua QuitadamoAntonio BoldriniMarco VuerichEmilio SigaliPatrizio FioriniLetizia PetrucciMarco MoroniFirenze MeyerPatrizia BragettiPaola CasucciLiliana MinelliDaniele MezzettiLuigi OrfeoMaria Gabriella De LucaNicola LaforgiaAlessandro GrassiAndrea DottaFerdinando SavignoniFranco BagnoliClaudio De FeliceSilvia BadiiAugusto BiasiniAntonio BelluzziMarcello StellaCostantino RomagnoliEnrico ZeccaGiovanni BaronePaolo ColleselliLuca VecchiatoSilvia NicolussiPaolo GilibertiGiovanni ChelloSilvana RojoMassimiliano De VivoChiara GiovanettoniClelia A. ColnaghiValeria ManfrediniElena VerucciGiulia PlacidiCesare BelloniGiuseppe CarreraChiara ZambettiPaolo BibanAlessandra SerraFrancesco SaccoGennaro VetranoGiuseppe FurcoloBrigida PasquarielloLuigi FalcoGaetano AusanioItalo BernardoAntonella CapassoGiuseppe MarchesanoNorberto NosariPaola SarnelliGiovanni CiraciDaniele MerazziDiego GazzoloFrancesca TemperiniMiriam SabatiniMicaela ColivicchiAntonio Del VecchioMarzia TarantinoGiancarlo GarganoSimona PedoriMassimo BellettatoRoberta PesaventoAlessandra CesaroMassimo ScolloIsabella MondelloAniello PuglieseClaudio IervolinoGiovanni CorselloMario GiuffrèPasqua BettaMario Giuseppe RomeoAlessandro SaporitoMaria Grazia LeoneAlessandro RodonòAlessia FranceschiFrancesco M. RissoMauro CarpentieriTeresa VecchianoMaria Pia CiglianoPiermichele PaolilloSimonetta PiconeAntonio MarraGessica RossettiTiziana TestaFernando Del CuoreFrancesco CrescenziGianna PoloniMaria Chiara RussoFrancesco NigroGabriella Lucia TinaPatrizia BrindisinoRaffaele GurradoMaurizio FeliceIsabella Formicasubject
MalePediatricsLogistic models; Mortality; Outcomes; Pregnancy complications; Preterm infants; Risks; Female; Gestational Age; Humans; Infant Newborn; Infant Premature Diseases; Male; Pregnancy; Pregnancy Outcome; Prospective Studies; Chorioamnionitis; Hypertension Pregnancy-Induced; Pediatrics Perinatology and Child Health; Medicine (all); Arts and Humanities (miscellaneous)DiseasesInfant Premature DiseasesChorioamnionitisoutcomesPediatricsPregnancyRisksMaternal hypertensionProspective StudiesriskObstetricspregnancy complicationsMedicine (all)Pregnancy OutcomeGestational ageRetinopathy of prematurityPerinatology and Child HealthChorioamnionitisSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICALogistic models Mortality Outcomes Pregnancy complications Preterm infants RisksNecrotizing enterocolitisHypertensionoutcomeFemaleHumanmedicine.medical_specialtyGestational AgeOutcomesPregnancy-Inducedpreterm infantPregnancy complicationArts and Humanities (miscellaneous)medicineLogistic models; Mortality; Outcomes; Pregnancy complications; Preterm infants; Risks; Female; Gestational Age; Humans; Infant Newborn; Infant Premature Diseases; Male; Pregnancy; Pregnancy Outcome; Prospective Studies; Chorioamnionitis; Hypertension Pregnancy-Induced; Pediatrics Perinatology and Child HealthHumanspreterm infantsMortalityPrematurelogistic modelPregnancyChorioamnionitibusiness.industryInfant NewbornPreterm infantsInfantInfant Premature DiseaseOdds ratioHypertension Pregnancy-Inducedmedicine.diseaseNewbornmortalityLogistic modelsProspective StudiePregnancy complicationsBronchopulmonary dysplasiaPediatrics Perinatology and Child Healthbusinesslogistic modelsrisksdescription
OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS: Overall mortality was higher after hypertension than after chorioamnionitis (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.08–1.80), but this relationship changed across GA weeks; the OR for hypertension was highest at low GA, whereas from 28 weeks' GA onward, mortality was higher for chorioamnionitis. For other outcomes, the relative risks were constant across GA; infants born after hypertension had an increased risk for bronchopulmonary dysplasia (OR, 2.20; 95% CI, 1.68–2.88) and severe retinopathy of prematurity (OR, 1.48; 95% CI, 1.02–2.15), whereas there was a lower risk for early-onset sepsis (OR, 0.25; 95% CI, 0.19–0.34), severe intraventricular hemorrhage (OR, 0.65; 95% CI, 0.48–0.88), periventricular leukomalacia (OR, 0.70; 95% CI, 0.48–1.01), and surgical necrotizing enterocolitis or gastrointestinal perforation (OR, 0.47; 95% CI, 0.31–0.72). CONCLUSIONS: Mortality and other adverse outcomes in very preterm infants depend on antecedents of preterm birth. Hypertension and chorioamnionitis are associated with different patterns of outcomes; for mortality, the effect changes across GA weeks.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 |