0000000000241462

AUTHOR

Hitesh Shetty

showing 3 related works from this author

Polypharmacy in people with dementia: Associations with adverse health outcomes

2018

Polypharmacy has been linked to higher risks of hospitalisation and death in community samples. It is commonly present in people with dementia but these risks have rarely been studied in this population. We aimed to investigate associations between polypharmacy and emergency department attendance, any and unplanned hospitalisation, and mortality in patients with dementia. Using a large mental health care database in South London, linked to hospitalisation and mortality data, we assembled a retrospective cohort of patients diagnosed with dementia. We ascertained number of medications prescribed at the time of dementia diagnosis and conducted multivariate Cox regression analyses. Of 4668 pati…

MaleAgingmedicine.medical_specialtyDatabases FactualPopulationBiochemistry03 medical and health sciences0302 clinical medicineEndocrinologyRisk FactorsLondonDementia; Emergency department; Hospitalisation; Mortality; Pharmacoepidemiology; PolypharmacyGeneticsmedicineHospitalisationDementiaHumans030212 general & internal medicineMortalityeducationMolecular BiologyAgedRetrospective StudiesPolypharmacyAged 80 and overeducation.field_of_studyProportional hazards modelbusiness.industryEmergency departmentPharmacoepidemiologyHazard ratioAttendanceRetrospective cohort studyCell BiologyEmergency departmentmedicine.diseaseSurvival AnalysisHospitalizationEmergency medicineMultivariate AnalysisPolypharmacyFemaleDementiabusinessEmergency Service Hospital030217 neurology & neurosurgery
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The Representativeness of Participants With Severe Mental Illness in a Psychosocial Clinical Trial

2018

Introduction: Cardiovascular morbidity and mortality are increased in severe mental illnesses (SMI). Trials of psychosocial health interventions to improve physical health in SMI, including in treatment-resistant schizophrenia, have shown some benefit. However, the representativeness of participants in such trials has not been determined. Method: We utilized an anonymised case register to determine if participants in a randomized controlled trial (RCT) of a novel psychosocial health intervention aiming to improve physical health in SMI had similar severity of illness to eligible non-participants. A retrospective database analysis was performed, using Health of the Nation Outcome Scale (HoNO…

medicine.medical_specialtylcsh:RC435-571PopulationPsychological interventionoutcomesHealth interventionlaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawlcsh:PsychiatrySeverity of illnessMedicinepsychosiseducationOriginal Researchhealth promotion interventionPsychiatryeducation.field_of_studybusiness.industrycardiovascularMental health030227 psychiatryClinical trialschizophreniaPsychiatry and Mental healthPhysical therapybusinessPsychosocial030217 neurology & neurosurgeryFrontiers in Psychiatry
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The relationship between Polypharmacy and Trajectories of Cognitive Decline in People with Dementia: a large representative cohort study

2019

Polypharmacy, defined through the number of medications prescribed, has been linked to a range of adverse health outcomes in people with dementia. It is however unclear whether a numerical threshold of concurrently prescribed drugs is a suitable predictor for cognitive decline. We aimed to test associations between polypharmacy and both short-term (six months) and long-term (three years) cognitive trajectories in patients with incident dementia. Using data from a large mental health and dementia care database in South London, a cohort of 12,148 patients (mean age = 80.7 years, 61.1% female, mean MMSE = 18.6) clinically diagnosed with dementia was identified. We determined the number of medi…

Male0301 basic medicineGerontologyAgingCognitive declineBiochemistryCohort Studies03 medical and health sciencesCognitionCommunity care0302 clinical medicineEndocrinologyA large representative cohort study.- Experimental gerontology cilt.120 ss.62-67 2019 [Soysal P. Perera G. Isik A. Onder G. Petrovic M. Cherubini A. Maggi S. Shetty H. Molokhia M. Smith L. et al. -The relationship between polypharmacy and trajectories of cognitive decline in people with dementia]mental disordersGeneticsmedicineHumansDementiaCognitive DysfunctionCognitive declineassociations between polypharmacyMolecular BiologyAgedAged 80 and overPolypharmacypeople with dementia.Mini–Mental State Examinationmedicine.diagnostic_testbusiness.industryCognition; Cognitive decline; Community care; Dementia; PolypharmacyCognitionlong-term (three years)Cell BiologyMental Status and Dementia Testsmedicine.diseaseComorbidity030104 developmental biologyCohortPolypharmacyFemaleDementiabusinessshort-term (six months)030217 neurology & neurosurgeryCohort study
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