0000000000241521

AUTHOR

Federica Lessi

showing 2 related works from this author

Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations

2016

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This pa…

Riskmedicine.medical_specialtySettore MED/06 - Oncologia Medicamedicine.medical_treatmentHematopoietic stem cell transplantationNeutropeniaSettore MED/17 - MALATTIE INFETTIVEHematopoietic stem cell transplantation; Leukemia; Molds; Risk factors; Yeast; Antineoplastic Combined Chemotherapy Protocols; Disease Susceptibility; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Invasive Fungal Infections; Risk; Hematology; OncologyHematopoietic stem cell transplantation; Leukemia; Molds; Risk factors; Yeast; Hematology; OncologyMolds03 medical and health sciences0302 clinical medicineInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansIn patientAspergillusHematologyLeukemiabiologyIncidence (epidemiology)IncidenceHematopoietic Stem Cell TransplantationHematologyhematopoietic stem cell transplantation; Leukemia; Molds; Risk factors; Yeastmedicine.diseasebiology.organism_classificationYeastSettore MED/15 - MALATTIE DEL SANGUELeukemiaOncologyRisk factorsMold030220 oncology & carcinogenesisHematologic NeoplasmsRisk stratificationImmunologyhematopoietic stem cell transplantationRisk factorDisease SusceptibilityInvasive Fungal Infections030215 immunology
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Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol

2022

Simple Summary IDH1/2 mutations are a common event in acute myeloid leukemia (AML) and represent a therapeutic target. We designed the GIMEMA AML1516 observational protocol to examine the prevalence of IDH1/2 mutations and the associations between IDH mutations and clinico-biological parameters in a cohort of Italian patients affected by AML. By analyzing 284 consecutive adult AML patients, we confirmed that IDH1 and IDH2 mutations are frequently detected-14% and 18%, respectively-at diagnosis. IDH1/2 mutations were significantly associated with an inferior performance status and non-complex karyotype when compared to IDH1/2-WT. With regards to the outcome, in the subset of IDH1/2-mutated p…

DH1Cancer ResearchOncologyAMLAML DH1 IDH2 prevalence prognosisprevalenceIDH2prognosisSettore MED/15AML; DH1; IDH2; prevalence; prognosis
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