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RESEARCH PRODUCT
Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations
Livio PaganoAlessandro BuscaAnna CandoniChiara CattaneoSimone CesaroRosa FanciGianpaolo NadaliLeonardo PotenzaDomenico RussoMario TumbarelloAnnamaria NosariFranco AversaFederica LessiMarianna CriscuoloFrancesca FarinaMaria Chiara TisiGloria TurriAngelica BaroneAngelica SpolzinoMaria Ilaria Del PrincipeAngela Maria QuintoRoberta Di BlasiLaura MaracciMitja NabergojBenedetta CambòAnna PegoraroFrancesco MarchesiSilvia PascaleAngela PassiMelania CarlisiNicola PolverelliBarbara BeggiaBenedetta RambaldiLucia PreziosoMarco Sannasubject
Riskmedicine.medical_specialtySettore MED/06 - Oncologia Medicamedicine.medical_treatmentHematopoietic stem cell transplantationNeutropeniaSettore MED/17 - MALATTIE INFETTIVEHematopoietic stem cell transplantation; Leukemia; Molds; Risk factors; Yeast; Antineoplastic Combined Chemotherapy Protocols; Disease Susceptibility; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Invasive Fungal Infections; Risk; Hematology; OncologyHematopoietic stem cell transplantation; Leukemia; Molds; Risk factors; Yeast; Hematology; OncologyMolds03 medical and health sciences0302 clinical medicineInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansIn patientAspergillusHematologyLeukemiabiologyIncidence (epidemiology)IncidenceHematopoietic Stem Cell TransplantationHematologyhematopoietic stem cell transplantation; Leukemia; Molds; Risk factors; Yeastmedicine.diseasebiology.organism_classificationYeastSettore MED/15 - MALATTIE DEL SANGUELeukemiaOncologyRisk factorsMold030220 oncology & carcinogenesisHematologic NeoplasmsRisk stratificationImmunologyhematopoietic stem cell transplantationRisk factorDisease SusceptibilityInvasive Fungal Infections030215 immunologydescription
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-17 |