0000000000241799

AUTHOR

Wolfram Windisch

showing 3 related works from this author

Long-term volume-targeted pressure-controlled ventilation: sense or nonsense?

2017

The technology underlying the development of novel ventilatory modes for long-term noninvasive ventilation of patients with chronic hypercapnia is continuously evolving. Volume-targeted pressure-controlled ventilation is a hybrid ventilation mode designed to combine the advantages of conventional ventilation modes, while avoiding their drawbacks. However, manufacturers have created different names and have patented algorithms and set-up variables, which can result in confusion for physicians and respiratory therapists. In addition, clear evidence for the superiority of this novel mode has not yet been established. These factors have most likely hindered more widespread use of this mode in c…

Pulmonary and Respiratory Medicinemedicine.medical_specialtySLEEP QUALITYPressure controlled ventilationChronic hypercapniaHOME MECHANICAL VENTILATIONOBSTRUCTIVE PULMONARY-DISEASEAMYOTROPHIC-LATERAL-SCLEROSISlaw.inventionHypercapnia03 medical and health sciences0302 clinical medicineOBESITY-HYPOVENTILATION SYNDROMElawACUTE RESPIRATORY-FAILUREmedicineCOPDHumansLEAKS030212 general & internal medicineIntensive care medicineRANDOMIZED CROSSOVER TRIALClinical Trials as TopicHybrid ventilationNoninvasive Ventilationbusiness.industryTerm (time)Clinical PracticeSUPPORT NONINVASIVE VENTILATION030228 respiratory systemEvaluation Studies as TopicVentilation (architecture)Noninvasive ventilationbusinessRespiratory InsufficiencyConventional ventilationHumanThe European respiratory journal
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Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

2019

Background & Aims Alpha-1 antitrypsin deficiency (AATD) is among the most common genetic disorders. Severe AATD is caused by a homozygous mutation in the SERPINA1 gene that encodes the Glu342Lys substitution (called the Pi*Z mutation, Pi*ZZ genotype). Pi*ZZ carriers may develop lung and liver diseases. Mutation-associated lung disorders have been well studied, but less is known about the effects in liver. We assessed the liver disease burden and associated features in adults with this form of AATD. Methods We collected data from 554 Pi*ZZ adults (403 in an exploratory cohort, 151 in a confirmatory cohort), in 9 European countries, with AATD who were homozygous for the Pi*Z mutation, and 234…

Liver CirrhosisMale0301 basic medicineALTLiver diseasechemistry.chemical_compound0302 clinical medicineLiver Function TestsRisk FactorsGenotypeRare Liver DiseaseAlpha 1-antitrypsin deficiencyHomozygoteAge FactorsGastroenterologyMiddle AgedEuropeEditorial CommentaryPhenotypemedicine.anatomical_structureLiverElasticity Imaging TechniquesFemale030211 gastroenterology & hepatologyTEAdultmedicine.medical_specialty610Mice Transgenic03 medical and health sciencesSex Factorsalpha 1-Antitrypsin DeficiencyInternal medicinemedicinePiAnimalsHumansGenetic Predisposition to DiseaseASTAgedLungHepatologyTriglyceridebusiness.industryLipid Metabolismmedicine.diseaseFatty Liver030104 developmental biologyEndocrinologychemistryCase-Control Studiesalpha 1-AntitrypsinMutationSteatosisTransient elastographybusinessGastroenterology
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ERS clinical practice guidelines:high-flow nasal cannula in acute respiratory failure

2022

BackgroundHigh-flow nasal cannula (HFNC) has become a frequently used noninvasive form of respiratory support in acute settings; however, evidence supporting its use has only recently emerged. These guidelines provide evidence-based recommendations for the use of HFNC alongside other noninvasive forms of respiratory support in adults with acute respiratory failure (ARF).Materials and methodologyThe European Respiratory Society task force panel included expert clinicians and methodologists in pulmonology and intensive care medicine. The task force used the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) methods to summarise evidence and develop clinical recommendat…

Pulmonary and Respiratory MedicineAdultmedicine.medical_specialtymedicine.medical_treatmentmedicine.disease_causeInternal medicineOxygen therapymedicineCannulaHumansAcute respiratory failureIntensive care medicineCOPDRespiratory Distress SyndromeNoninvasive Ventilationbusiness.industryOxygen Inhalation Therapychronic respiratory failure - COPD - noinvasive ventilationmedicine.diseaseClinical PracticeOxygenPulmonologyBreathingHigh flowbusinessRespiratory InsufficiencyNasal cannula
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