0000000000243995

AUTHOR

Di Marco

showing 5 related works from this author

Sorafenib: from literature to clinical practice

2013

Sorafenib is considered the standard systemic therapy for hepatocellular carcinoma (HCC), in patients with well-preserved liver function (Child-Pugh A class) and advanced-stage HCC (BCLC-C) or in patients with HCC progressing after locoregional therapies, with a high grade of recommendation. The approval of sorafenib for this indication was grounded on the efficacy and the safety results reported by two international randomized, controlled trials, the SHARP and the Asia-Pacific studies. In addition, the efficacy and the safety of sorafenib in clinical practice are addressed by several field-practice experiences, including the multinational GIDEON study and the SOFIA study. Finally, further …

OncologyTime Factorsadverse eventPharmacologySystemic therapylaw.inventionTranslational Research Biomedicalobservational studieAntineoplastic AgentRandomized controlled trialRisk FactorslawMolecular Targeted TherapyHCCTranslational Medical Researchadverse events; clinical practice; observational studies; randomized clinical trials; sorafenib; Animals; Antineoplastic Agents; Carcinoma Hepatocellular; Evidence-Based Medicine; Humans; Liver Neoplasms; Neoplasm Staging; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Treatment Outcome; Molecular Targeted Therapy; Translational Medical ResearchRandomized Controlled Trials as TopicEvidence-Based MedicineLiver NeoplasmsHematologyclinical practiceTreatment OutcomeOncologyLiver NeoplasmHepatocellular carcinomaHumanmedicine.drugNiacinamidePhenylurea CompoundSorafenibmedicine.medical_specialtyCarcinoma HepatocellularTime FactorProtein Kinase InhibitorAntineoplastic AgentsInternal medicinemedicineAnimalsHumansAdverse effectProtein Kinase InhibitorsneoplasmsNeoplasm StagingAnimalbusiness.industryPhenylurea CompoundsRisk FactorEvidence-based medicinerandomized clinical trialmedicine.diseasedigestive system diseasessorafenibObservational studyLiver functionbusiness
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Kinetic analysis of insulin resistance and serum adipocytokines levels during peginterferon alpha-2A plus ribavirin therapy in non-diabetic HCV patie…

2006

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Breaking bad news: How to cope.

2018

Physicians often are uncomfortable when communicating an unfavorable outcome: they feel inadequate in the face of uncontrollable disease and unprepared to manage the emotional reactions of patients. For lack of proper training, they often adopt inappropriate ways to disclose unfavorable information. We will outline some key points about the issue of disclosing bad news and aim to provide useful tools to physicians who have to cope frequently with breaking bad news to patients, providing examples and clinical sceneries specific to gastroenterology and hepatology practice.

Medical educationPhysician-Patient RelationsTruth DisclosureHepatologybusiness.industrymedia_common.quotation_subjectCommunicationMedical HumanitieGastroenterologyMEDLINEHepatology; Gastroenterology; Communication; Bad news; Medical Humanities; EmpathyEmpathyTruth Disclosure03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisBad newMedicineHumans030211 gastroenterology & hepatologyMedical humanitiesEmpathybusinessmedia_commonDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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Fibrosis staging in chronic hepatitis C: Analysis of discordance between transient elastography and liver biopsy

2009

Summary.  In chronic hepatitis C, transient elastography (TE) accurately identifies cirrhosis, but its ability to assess significant fibrosis (Metavir ≥ F2) is variable. Constitutional and liver disease-related factors may influence TE and here we examined the variables associated with differences. Three hundred consecutive hepatitis C virus (HCV)-RNA positive patients had biochemical tests, TE and a biopsy performed on the same day. The Dale model was used to identify the variables associated with discordance between biopsy and elastography results. In 97 patients (34.2%), TE and histological assessment were discordant. Seventy-six of 286 (26.6%) had stage ≥F2 and TE < 7.1 kPa (false negat…

AdultLiver CirrhosisMalemedicine.medical_specialtyPathologyCirrhosisTransient elastographyHepatitis C virusBiopsyLiver fibrosismedicine.disease_causeGastroenterologySeverity of Illness IndexAminotranferases; Liver fibrosis; Transient elastography; Adult; Diagnostic Errors; Female; Hepatitis C Chronic; Histocytochemistry; Humans; Liver Cirrhosis; Male; Middle Aged; ROC Curve; Transaminases; Biopsy; Elasticity Imaging Techniques; Severity of Illness Index; Hepatology; Infectious Diseases; Virology; Medicine (all)Liver diseaseInternal medicineVirologyBiopsymedicineHumansDiagnostic ErrorsChronicAminotranferases liver fibrosis transient elastographyTransaminasesmedicine.diagnostic_testReceiver operating characteristicHepatologybusiness.industryHistocytochemistryMedicine (all)Hepatitis CHepatitis C ChronicMiddle Agedmedicine.diseaseHepatitis CInfectious DiseasesROC CurveLiver biopsyAminotranferasesElasticity Imaging TechniquesFemaleTransient elastographybusiness
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Long-term interferon-α treatment of children with chronic hepatitis delta: A multicentre study

1996

We assessed the efficacy of prolonged interferon-alpha (IFN) therapy in children with chronic hepatitis caused by hepatitis delta virus (HDV) by treating 26 paediatric cases with IFN-alpha 2b (5 MU m-2, then 3 MU m-2 three times weekly for 12 (medium-term group MTG) or 24 months (long-term group, LTG). Compliance and tolerability were acceptable. At the end of therapy a complete biochemical response [normalization of alanine aminotransferase (ALT)] occurred in 12 children (5/13 in MTG and 7/13 in LTG). A relapse occurred after stopping IFN in 10 cases (five in MTG and five in LTG). Two patients from the LTG had normal liver function tests during 12 months of follow-up. Six of the eight hepa…

Malemedicine.medical_specialtyHepatitis B virusAdolescentmedicine.disease_causeGastroenterologyAntiviral AgentsVirusAntigenChronic hepatitisVirologyInternal medicinemedicineHumansHepatitis B e AntigensChildAntigens ViralHepatitisHepatitis B virusHepatologybusiness.industryInterferon-alphaAlanine Transaminasemedicine.diseaseHepatitis DRecombinant ProteinsClinical trialInfectious DiseasesHBeAgTolerabilityImmunologyChronic DiseaseDNA ViralInterferon Type IPatient ComplianceRNA ViralFemaleHepatitis Delta Virusbusiness
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