0000000000244037

AUTHOR

Michaela Kerstin Müller

showing 2 related works from this author

Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.

2020

AbstractAmyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer’s disease, yet its physiological functions remain incompletely understood. Previous studies had indicated important synaptic functions of APP and the closely related homologue APLP2 in excitatory forebrain neurons for spine density, synaptic plasticity, and behavior. Here, we show that APP is also widely expressed in several interneuron subtypes, both in hippocampus and cortex. To address the functional role of APP in inhibitory neurons, we generated mice with a conditional APP/APLP2 double knockout (cDKO) in GABAergic forebrain neurons using DlxCre mice. These DlxCre cDKO mice exhibit cognitive deficits i…

InterneuronCognitive NeuroscienceLong-Term PotentiationSpatial LearningHippocampusAction PotentialsInhibitory postsynaptic potentialHippocampusNesting Behavior03 medical and health sciencesCellular and Molecular NeuroscienceAmyloid beta-Protein PrecursorMice0302 clinical medicineCognitionProsencephalonAmyloid precursor proteinmedicineAnimalsGABAergic NeuronsCA1 Region Hippocampal030304 developmental biologySpatial MemoryMice Knockout0303 health sciencesNeuronal PlasticitybiologyPyramidal CellsExcitatory Postsynaptic PotentialsLong-term potentiationmedicine.anatomical_structurenervous systemInhibitory Postsynaptic PotentialsSynaptic plasticityForebrainExcitatory postsynaptic potentialbiology.proteinNeuroscience030217 neurology & neurosurgeryCerebral cortex (New York, N.Y. : 1991)
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Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

2018

AbstractSevere infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly,…

0301 basic medicineMaleInterneuronOffspringNeurogenesisMothersInflammationBiologyInhibitory postsynaptic potentialArticle03 medical and health sciencesCellular and Molecular NeuroscienceMice0302 clinical medicineNeuroblastCell MovementInterneuronsPregnancyPrecursor cellmedicineAnimalsCognitive DysfunctionGABAergic NeuronsMolecular BiologyCell ProliferationCerebral CortexInflammationPregnancyCell growthNeurogenesisCognitionmedicine.diseaseMice Inbred C57BLPsychiatry and Mental health030104 developmental biologymedicine.anatomical_structurenervous systemPrenatal Exposure Delayed EffectsGABAergicFemalemedicine.symptomPsychiatric disordersNeuroscience030217 neurology & neurosurgeryNeuroscience
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