0000000000244900
AUTHOR
Giuliano Da
Unilateral Nigral Lesion Induces Dramatic Bilateral Modification In Rat Brain Monoamine Levels: A Neurochemical Study.
Descrizione di un caso di acalasia in soggetto sottoposto a laringectomia totale
L’acalasia è una disfunzione della motilità esofagea contrassegnata dall’assenza della peristalsi e da assente o incompleto rilasciamento dello sfintere esofageo inferiore. Viene descritto il caso di un paziente divenuto acalasico dopo intervento di laringectomia totale allo scopo di comprendere i meccanismi fisiopatologici che possono aver determinato l’insorgenza di tale complicanza.
7-Nitroindazole protects striatal neurons against MPP+ -induced degeneration.
The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc). In this study, using a microdialysis technique, we investigated whether an inhibitor of neuronal nitric oxide synthase (nNOS), 7-nitrindazole (7-NI), could protect against DAergic neuronal damage induced by in vivo infusion of 1-methyl-4-phenylpiridinium iodide (MPP+) in freely moving rats. Experiments were performed over 2 days in three groups of rats: (a) nonlesioned, (b) MPP+-lesioned, and (c) 7-NI pretreated MPP+-lesioned rats. On day 1, control rats were perfused with an artificial CSF, while 1 mM MPP+ was infused into t…